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Inositol nicotinate

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Inositol nicotinate Basic information

Product Name:
Inositol nicotinate
Synonyms:
  • MYO-INOSITOL HEXANICOTINATE
  • MYO-INOSITOL HEXA-3-PYRIDINECARBOXYLATE
  • INOSITOL HEXANICOTINATE
  • inositol hexa-3-pyridinecarboxylate
  • INOSITOL NIACINATE
  • INOSITOL NICOTINATE
  • dilcit
  • dilexpal
CAS:
6556-11-2
MF:
C42H30N6O12
MW:
810.72
EINECS:
229-485-9
Product Categories:
  • Circulatory system agents
  • Nutritional fortification substances
  • Organics
  • Nutritional Supplements
  • 6556-11-2
Mol File:
6556-11-2.mol
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Inositol nicotinate Chemical Properties

Melting point:
254-256 °C(lit.)
Boiling point:
755.54°C (rough estimate)
Density 
1.3348 (rough estimate)
refractive index 
1.6400 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Aqueous Acid (Slightly, Heated), DMSO (Slightly, Heated, Sonicated)
pka
3.92±0.10(Predicted)
form 
Solid
color 
White to Off-White
Merck 
13,5002
InChI
InChI=1S/C42H30N6O12/c49-37(25-7-1-13-43-19-25)55-31-32(56-38(50)26-8-2-14-44-20-26)34(58-40(52)28-10-4-16-46-22-28)36(60-42(54)30-12-6-18-48-24-30)35(59-41(53)29-11-5-17-47-23-29)33(31)57-39(51)27-9-3-15-45-21-27/h1-24,31-36H/t31-,32-,33-,34+,35-,36-
InChIKey
MFZCIDXOLLEMOO-GYSGTQPESA-N
SMILES
[C@@H]1(OC(C2=CC=CN=C2)=O)[C@@H](OC(C2=CC=CN=C2)=O)[C@H](OC(C2=CC=CN=C2)=O)[C@@H](OC(C2=CC=CN=C2)=O)[C@H](OC(C2=CC=CN=C2)=O)[C@@H]1OC(C1=CC=CN=C1)=O
LogP
3.945 (est)
CAS DataBase Reference
6556-11-2(CAS DataBase Reference)
EPA Substance Registry System
Inositol nicotinate (6556-11-2)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
2
RTECS 
NM7535400

MSDS

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Inositol nicotinate Usage And Synthesis

Originator

Hexanicotol,Philadelphia,US,1962

Uses

benzidine substitute

Uses

myo-Inositol Hexanicotinate is an nicotinate conjugate of myo-inositol, an structural basis for a number of secondary messengers.

Definition

ChEBI: Inositol hexanicotinate is an inositol nicotinate. It is functionally related to a nicotinic acid.

Manufacturing Process

100 g of nicotinic acid were suspended in 265 ml of distilled and dried pyridine without stirring. 68 g of phosphorus oxychloride were added dropwise to this mixture under continual stirring. The temperature of the reactants, initially at 20°C, was allowed to rise to about 60°C, and this temperature was maintained for a further 60 minutes. Thereafter 24.5 g of meso-inositol wereadded gradually, the temperature being controlled so that it did not exceed about 80°C. The reactants were maintained at this temperature for from 2 to 3 hours, and thereafter the reaction mixture was poured into 500 ml of water. The pyridine salts formed during the reaction readily dissolved, and the mesoinositol hexanicotinate which had formed crystallized out. The ester was filtered off and washed with water and acetone or alcohol. Finally, the mesoinositol hexanicotinate was dried at 100°C.
The yield was 90%, the melting point of the product was 258°C to 260°C. and the chlorine content <0.01%.

brand name

Hexopal (Sterling Winthrop); Linodil (Sterling Winthrop); Palohex (Sterling Winthrop).

Therapeutic Function

Vasodilator

Clinical Use


Peripheral vascular disease

Hyperlipidaemia

Drug interactions

Potentially hazardous interactions with other drugs
Statins: increased risk of myopathy.

Metabolism

Inositol nicotinate is believed to be slowly hydrolysed to nicotinic acid. The main route of metabolism is then conversion to N-methylnicotinamide and the 2-pyridone and 4-pyridone derivatives; nicotinuric acid is also formed.
Small amounts of nicotinic acid are excreted unchanged in urine.

Inositol nicotinate Supplier

Xi'an Laina Biotechnology Co., Ltd Gold
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0573-85285100 18627885956
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