OPHIOBOLIN B
OPHIOBOLIN B Basic information
- Product Name:
- OPHIOBOLIN B
- Synonyms:
-
- OPHIOBOLIN B
- 3,14-Dihydroxy-5-oxoophiobola-7,19-dien-25-al
- Cochliobolin B
- Cochliobolin B, Zizanin B, Ophiobolsin A
- Dicyclopenta[a,d]cyclooctene-4-carboxaldehyde, 7-[(1S)-1,5-dimethyl-4-hexen-1-yl]-1,2,3,3a,6,6a,7,8,9,9a,10,10a-dodecahydro-1,7-dihydroxy-1,9a-dimethyl-3-oxo-, (1R,3aS,6aR,7S,9aR,10aS)-
- Ophiobolin B (Cochliobolin B)
- CAS:
- 5601-74-1
- MF:
- C25H38O4
- MW:
- 402.57
- Mol File:
- 5601-74-1.mol
OPHIOBOLIN B Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
- form
- White to off-white solid.
OPHIOBOLIN B Usage And Synthesis
Uses
Calmodulin is a calcium-sensing protein that regulates a wide array of proteins involved in diverse cellular functions. Ophiobolin B is a sesterterpenoid fungal phytotoxin that binds and irreversibly antagonizes calmodulin, producing cytotoxic and antimicrobial effects. It induces apoptosis in chronic lymphocytic leukemia cells with an LC50 value of 2 nM and in different zygomycetes with MIC values ranging from 25-50 μg/ml.[Cayman Chemical]
Uses
Ophiobolin B is a fungal phytotoxin and inhibits calmodulin (a protein involved in calcium regulation). Ophiobolin B also exhibit antibacterial and antitumor activities.
Uses
Ophiobolin B is a minor member of a class of phytotoxic metabolites produced by Bipolaris and other genera of plant pathogenic fungi. Ophiobolin B acts by inhibiting calmodulin action in calcium regulation.
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