Triptonide
Triptonide Basic information
- Product Name:
- Triptonide
- Synonyms:
-
- TRIPTONIDE
- TRIPTONIDE(PRIMARY STANDARD)
- NSC 165677
- PG 492
- (3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-6a-Isopropyl-8b-methyl-3b,4,4a,7a,7b,8b,9,10-octahydrotrisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione
- 14-Deoxy-14-oxotriptolide
- Triptolide,14-deoxy-14-oxo
- Triptonide, 98%, from Peucedanum praeruptorum Dunn
- CAS:
- 38647-11-9
- MF:
- C20H22O6
- MW:
- 358.39
- Product Categories:
-
- Heterocycles
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 38647-11-9.mol
Triptonide Chemical Properties
- Melting point:
- 251～252℃
- Boiling point:
- 581.1±50.0 °C(Predicted)
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Dichloromethane (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Off-White to Pale Beige
- InChIKey
- SWOVVKGLGOOUKI-PBIZPCRONA-N
- SMILES
- C[C@]12CCC3C(=O)OCC=3[C@]1([H])C[C@@H]1O[C@]31C([C@@]1(C(C)C)O[C@H]1[C@@H]1O[C@]231)=O |&1:1,10,13,15,17,22,23,25,r|
Triptonide Usage And Synthesis
Chemical Properties
Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Tripterygium wilfordii.
Uses
Triptonide is a Triptolide (T815600) analogue used in the preparation of cytotoxic fluorinated Triptolide.
Definition
ChEBI: Triptonide is a diterpene triepoxide that is triptobenzene K in which the acylhydroquinone moiety has undergone oxidation to the corresponding triepoxyketone derivative. It has been isolated from the roots of Tripterygium wilfordii. It has a role as an antineoplastic agent, an anti-inflammatory agent and an immunosuppressive agent. It is a cyclic ketone, an organic heteroheptacyclic compound, a diterpene triepoxide and a butenolide.
in vivo
Triptonide (5 mg/kg; i.p.; daily; for 34 days) exerts a strong anti-lymphoma effect in mice[2].
| Animal Model: | Eight-week-old female NOD/SCID mice (18-22 g), with 3 x 107 Raji cells xenograft[2] |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection, daily, for 34 days |
| Result: | Potently inhibited lymphoma cell growth and tumorigenic capability. |
target
ERK | IL Receptor | GSK-3 | p38MAPK | Wnt/β-catenin
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Triptonide(38647-11-9)Related Product Information
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