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Triptonide

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Triptonide Basic information

Product Name:
Triptonide
Synonyms:
  • TRIPTONIDE
  • TRIPTONIDE(PRIMARY STANDARD)
  • NSC 165677
  • PG 492
  • (3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-6a-Isopropyl-8b-methyl-3b,4,4a,7a,7b,8b,9,10-octahydrotrisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione
  • 14-Deoxy-14-oxotriptolide
  • Triptolide,14-deoxy-14-oxo
  • Triptonide, 98%, from Peucedanum praeruptorum Dunn
CAS:
38647-11-9
MF:
C20H22O6
MW:
358.39
Product Categories:
  • Heterocycles
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
38647-11-9.mol
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Triptonide Chemical Properties

Melting point:
251～252℃
Boiling point:
581.1±50.0 °C(Predicted)
Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Dichloromethane (Slightly), Methanol (Slightly)
form 
Solid
color 
Off-White to Pale Beige
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Triptonide Usage And Synthesis

Uses

Triptonide is a Triptolide (T815600) analogue used in the preparation of cytotoxic fluorinated Triptolide.

Definition

ChEBI: Triptonide is a diterpene triepoxide that is triptobenzene K in which the acylhydroquinone moiety has undergone oxidation to the corresponding triepoxyketone derivative. It has been isolated from the roots of Tripterygium wilfordii. It has a role as an antineoplastic agent, an anti-inflammatory agent and an immunosuppressive agent. It is a cyclic ketone, an organic heteroheptacyclic compound, a diterpene triepoxide and a butenolide.

target

ERK | IL Receptor | GSK-3 | p38MAPK | Wnt/β-catenin

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