7-Nitroindole Chemical Properties

Melting point:

94-98 °C (lit.)

Boiling point:

288.82°C (rough estimate)

Density 

1.3264 (rough estimate)

refractive index 

1.5770 (estimate)

storage temp. 

Sealed in dry,Room Temperature

form 

powder to crystal

pka

13.96±0.30(Predicted)

color 

Light yellow to Yellow to Orange

Water Solubility 

slightly soluble

BRN 

130874

CAS DataBase Reference

6960-42-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

68

Safety Statements 

36/37-45

WGK Germany 

3

RTECS 

NM1169000

Hazard Note 

Irritant

HazardClass 

IRRITANT-HARMFUL

HS Code 

29339900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

7-Nitroindole Usage And Synthesis

Chemical Properties

yellow crystalline powder

Uses

7-Nitroindole is a reagent used in chemical synthesis. It has been used in the synthesis of protein kinase and inosine monophosphate inhibitors, beta3 agonists and CCK-1 receptor modulators. 7-Nitroindole has also been used as a photochemical precursor of the 2'-deoxyribonolactone analog.

Uses

7-Nitroindole is a useful reactant for the preparation of various compounds and inhibitors.

Uses

Reactant for preparation of:

• Protein kinase inhibitors
• Potential fructose 1,6-bisphosphatase inhibitors
• Factor Xa inhibitors
• Antagonist of the mineralocorticoid receptor
• Antitumor sulfonamides
• Inosine monophosphate dehydrogenase (IMPDH) inhibitors
• Subtype-selective cyclooxygenase (COX) inhibitors
• Thrombin protease-activated receptor (PAR-1) ligands

Application

Reactant for preparation of:
Protein kinase inhibitors
Potential fructose 1,6-bisphosphatase inhibitors
Factor Xa inhibitors
Antagonist of the mineralocorticoid receptor
Antitumor sulfonamides
Inosine monophosphate dehydrogenase (IMPDH) inhibitors
Subtype-selective cyclooxygenase (COX) inhibitors
Thrombin protease-activated receptor (PAR-1) ligands

Synthesis Reference(s)

Canadian Journal of Chemistry, 42, p. 1235, 1964 DOI: 10.1139/v64-189

7-Nitroindole(6960-42-5)Related Product Information

• 4-Nitroindole
• 7-hydroxy-7-phenylheptanoic acid(Seratrodast inteMediate)
• 7-CHLOROIMIDAZO[1,2-A]PYRIDINE
• 5-BROMO-7-NITROINDOLE
• 7-NITROINDOLE-3-ALDEHYDE,7-NITROINDOLE-3-CARBOXALDEHYDE,7-NITROINDOLE-3-CARBOXYALDEHYDE
• 2,3-Dimethyl-7-nitroindole
• 7-NITROINDOLE-2-CARBOXYLIC ACID
• 7-NITROINDOLE-2-CARBOXYLIC ACID ETHYL ESTER,ETHYL 7-NITROINDOLE-2-CARBOXYLATE
• 5-Methyl-4-nitroindole
• 5-Nitroindole-2-carboxylic acid
• 6-Nitroindoline
• 5-NITROINDOLE
• 3',3'-Dimethyl-6-nitro-spiro[2H-1-benzopyran-2,2'-indoline]-1'-ethanol
• 5-NITROOXINDOLE
• 5-Nitroindoline
• 3-Formyl-5-methoxy-1-methyl-4-nitroindole
• 3-Methyl-6-nitroindole
• 5-NITROINDOLE-3-ACETONITRILE