Tegaserod Chemical Properties

Melting point:

155°

Boiling point:

470.6±48.0 °C(Predicted)

Density 

1.18

storage temp. 

2-8°C

form 

Solid

pka

15.81±0.30(Predicted)

color 

White to off-white

CAS DataBase Reference

145158-71-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

36/37-36-26

Tegaserod Usage And Synthesis

Uses

Treatment of gastrointestinal motility disorders (selective serotonin 5HT4antagonist).

Indications

Tegaserod (Zelnorm) is serotonin-4 (5-HT4) receptor agonists that stimulate GI motility.

Definition

ChEBI: Tegaserod is a member of guanidines, a carboxamidine, a member of hydrazines and a member of indoles. It has a role as a serotonergic agonist and a gastrointestinal drug.

brand name

Zelmac (Novartis).

Clinical Use

Tegaserod is being developed as a treatment for constipation- predominant irritable bowel syndrome (IBS). Within the first week, patients treated with tegaserod had significant improvements in abdominal pain and discomfort, constipation, and overall well-being. Efficacy was maintained throughout the treatment period. Tegaserod also demonstrated significant improvements in the three bowel-related assessments (stool frequency, stool consistency, and straining) within the first week, and these improvements were sustained throughout the treatment period. The most common adverse events reported thus far are headache and diarrhea.

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