Tiapride hydrochloride Chemical Properties

Melting point:

approximate 200℃ (dec.)

storage temp. 

2-8°C

solubility 

Very soluble in water, soluble in methanol, slightly soluble in anhydrous ethanol.

form 

Solid

color 

White

Merck 

14,9421

CAS DataBase Reference

51012-33-0(CAS DataBase Reference)

Safety Information

WGK Germany 

2

RTECS 

CV4203800

HS Code 

2930.90.2900

MSDS

• Language:English Provider:SigmaAldrich

Tiapride hydrochloride Usage And Synthesis

Chemical Properties

White Solid

Originator

Tiapridal,Delagrange,France,1977

Uses

Tiapride is a D2 and D3 dopamine receptor antagonist and a antipsychotic drug predominately used in the pharmacotherapy of patients with dementia.

Uses

Dopamine antagonist;Antidyskinetic

Uses

Tiapride hydrochloride is a D2 and D3 dopamine receptor antagonist and a antipsychotic drug predominately used in the pharmacotherapy of patients with dementia.

Definition

ChEBI: Tiapride hydrochloride is a member of benzamides.

Manufacturing Process

5 g of 2-methoxy-5-methylsulfonylbenzoic acid, 50 ml of dioxan, 3.02 ml of triethylamine and 3 g of isobutyl chloroformate were introduced into a 250 ml balloon flask at ambient temperature.
After the mixture had been stirred for 30 minutes, 3 g of N,N_x0002_diethylethylenediamine were added. The reaction mixture was stirred for 6 hours and the solvents were evaporated under vacuum.
The residue was dissolved in 50 ml of water and the solution was made alkaline with sodium hydroxide. The precipitate formed was filtered, washed and dried in a drying oven at 60°C. 6 g of N-(diethylaminoethyl)-2-methoxy- 5-methylsulfonylbenzamide (melting point: 124°C to 125°C) was produced.

Therapeutic Function

Antiemetic

Tiapride hydrochloride(51012-33-0)Related Product Information

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