Ethyl propiolate Chemical Properties

Melting point:

9°C

Boiling point:

120 °C (lit.)

Density 

0.968 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.412(lit.)

Flash point:

74 °F

storage temp. 

2-8°C

solubility 

Miscible with alcohol.

form 

Liquid

Specific Gravity

0.968

color 

Clear colorless to pale yellow

Water Solubility 

miscible

Merck 

14,3846

BRN 

878250

Dielectric constant

7.0

CAS DataBase Reference

623-47-2(CAS DataBase Reference)

NIST Chemistry Reference

Ethyl propiolate(623-47-2)

Safety Information

Hazard Codes 

Xi,F

Risk Statements 

10-36/37/38-36-11

Safety Statements 

26-36-37/39-16-33-29-24-23

RIDADR 

UN 3272 3/PG 3

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

3

PackingGroup 

II

HS Code 

29161980

MSDS

• Language:English Provider:Ethyl propiolate
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
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Ethyl propiolate Usage And Synthesis

Chemical Properties

Ethyl propiolate is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.

Uses

Halogenated derivatives were used as substrates for direct, asymmetric alkynylation of cyclic ?-ketoesters using chiral phase-transfer catalysts. Also employed in a one-pot , four-component synthesis of benzene-1,2,3,5-tetracarboxylates promoted by Ph3P.

Uses

Ethyl propiolate is used as a precursor in the preparation of substituted anthraquinones and pyrazolo[1,5-a]pyridine, which exhibits anti-inflammatory activity. Further, it is employed in the synthesis of benzene-1,2,3,5-tetracarboxylates promoted by triphenylphosphine. Its halogenated derivatives are used as a substrate for direct, asymmetric alkynylation of cyclic beta-ketoesters using chiral phase-transfer catalysts.

Uses

In organic synthesis; peptide coupling reagent.

Definition

ChEBI: Ethyl propiolate is the ethyl ester of prop-2-ynoic acid. It is a ynoate ester, a terminal acetylenic compound and an ethyl ester.

Hazard

Flammable; lachrymator.

Ethyl propiolate(623-47-2)Related Product Information

• Propiolic Acid
• Ethyl acetate
• Ethyl phenylacetate
• Trinexapac-ethyl
• Ethyl formate
• Ethylparaben
• ISOXADIFEN-ETHYL
• Ethyl acetoacetate
• Tetraethyl orthosilicate
• Ethyl acrylate
• Ethyl cyanoacetate
• Ethyl Hexanoate
• Ethanol
• Methyl propiolate
• PROPYNOIC ACID AMIDE
• ETHYL 2-HEXYNOATE
• ETHYL PHENYLPROPIOLATE
• TERT-BUTYL PROPIOLATE