Tiapride Chemical Properties

Melting point:

123-125°

vapor pressure 

0Pa at 25℃

storage temp. 

2-8°C

pka

9.14[at 20 ℃]

Water Solubility 

349mg/L at 25℃

LogP

0.9

CAS DataBase Reference

51012-32-9(CAS DataBase Reference)

Safety Information

WGK Germany 

2

RTECS 

CV4203800

MSDS

• Language:English Provider:N-[2-(Diethylamino)ethyl]-2-methoxy-5-(methylsulphonyl)benzamide

Tiapride Usage And Synthesis

Originator

Tiapridal,Delagrange,France,1977

Uses

diuretic, antihypertensive

Uses

Tiapride hydrochloride is a D2DR and D3DR inhibitor; Anti-psychotic agent and alternative treatment for Tourette’s syndrome.

Definition

ChEBI: N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide is a member of benzamides.

Manufacturing Process

5 g of 2-methoxy-5-methylsulfonylbenzoic acid, 50 ml of dioxan, 3.02 ml of triethylamine and 3 g of isobutyl chloroformate were introduced into a 250 ml balloon flask at ambient temperature.
After the mixture had been stirred for 30 minutes, 3 g of N,N_x0002_diethylethylenediamine were added. The reaction mixture was stirred for 6 hours and the solvents were evaporated under vacuum.
The residue was dissolved in 50 ml of water and the solution was made alkaline with sodium hydroxide. The precipitate formed was filtered, washed and dried in a drying oven at 60°C. 6 g of N-(diethylaminoethyl)-2-methoxy- 5-methylsulfonylbenzamide (melting point: 124°C to 125°C) was produced.

brand name

Tiapride Hydrochloride is JAN.

Therapeutic Function

Antiemetic

Tiapride(51012-32-9)Related Product Information

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