N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Chemical Properties

Boiling point:

391.1±37.0 °C(Predicted)

Density 

1.175±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

3.62±0.10(Predicted)

InChI

InChI=1S/C10H19NO5/c1-9(2,3)16-8(14)11-6(7(12)13)10(4,5)15/h6,15H,1-5H3,(H,11,14)(H,12,13)/t6-/m0/s1

InChIKey

SZVRVSZFEDIMFM-LURJTMIESA-N

SMILES

C(O)(=O)[C@@H]([C@@](C)(O)C)NC(OC(C)(C)C)=O

CAS DataBase Reference

288159-40-0

Safety Information

HazardClass 

IRRITANT

HS Code 

29225090

N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Usage And Synthesis

Chemical Properties

White powder

Synthesis

General procedure for the synthesis of (R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid from tert-butyl (S)-(1,3-dihydroxy-3-methylbutan-2-yl)carbamate: [Step 3] Synthesis of (R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid: at -35 °C, an aqueous solution of sodium hypochlorite (5.0 mL, containing 0.8 g, 0.64 mmol) and aqueous sodium hypochlorite (10 mL, containing 2.4 g, 27 mmol) were added simultaneously and slowly to an acetonitrile containing Reference Example Compound 36 (2.8 g, 13 mmol), 2,2,6,6-tetramethylpiperidinium 1-yloxy (0.40 g, 2.6 mmol), and a standard neutral phosphate buffer (45 mL) (50 mL) solution. The reaction solution was stirred at -35 °C for 3 h. Acetic acid (1.0 mL) was added. Stirring was continued at -35°C for 3 hours, followed by the addition of water and extraction with ethyl acetate. The organic layer was washed sequentially with water and saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting crude product was dissolved in saturated aqueous sodium bicarbonate solution and washed with ethyl acetate. The aqueous layer was acidified with 3N hydrochloric acid and extracted again with ethyl acetate. The organic layer was washed with water and saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 2.5 g (84% yield) of (R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid (hereinafter referred to as Reference Example Compound 37).

References

[1] Journal of Organic Chemistry, 2003, vol. 68, # 1, p. 177 - 179
[2] Nature Chemistry, 2010, vol. 2, # 4, p. 280 - 285
[3] Patent: EP2832724, 2015, A1. Location in patent: Paragraph 0188

N-BOC-(R)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID(288159-40-0)Related Product Information

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