2-IODOBENZOYL CHLORIDE Chemical Properties

Melting point:

27-31 °C(lit.)

Boiling point:

105-106 °C1 mm Hg(lit.)

Density 

1.932

Flash point:

>110°C

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

soluble in Toluene

form 

powder to lump

color 

White to Light yellow to Dark green

Water Solubility 

Reacts with water.

Sensitive 

Moisture & Light Sensitive

BRN 

2042672

InChIKey

MVIVDSWUOGNODP-UHFFFAOYSA-N

CAS DataBase Reference

609-67-6(CAS DataBase Reference)

EPA Substance Registry System

Benzoyl chloride, 2-iodo- (609-67-6)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3261 8/PG 2

WGK Germany 

3

F 

21-19

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29163990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-IODOBENZOYL CHLORIDE Usage And Synthesis

Chemical Properties

white to pinkish or pale yellow crystalline

Uses

2-Iodobenzoyl chloride has been used in palladium-catalyzed synthesis of carbomethoxy functional group-induced isoindolin-1-ones, preparation of starting materials required for the synthesis of novel cyclic derivatives of pentavalent iodine, benziodazole oxides.

Uses

2-Iodobenzoyl chloride has been used in:

• palladium-catalyzed synthesis of carbomethoxy functional group-induced isoindolin-1-ones
• preparation of starting materials required for the synthesis of novel cyclic derivatives of pentavalent iodine, benziodazole oxides

Synthesis

General method: 2-iodobenzoic acid (1.0 mmol) was mixed with excess thionyl chloride (5 mL) and reacted at reflux for 2 hours. Upon completion of the reaction, the excess thionyl chloride was removed by vacuum concentration to give o-iodobenzoyl chloride in quantitative yield.

References

[1] Journal of Medicinal Chemistry, 1994, vol. 37, # 12, p. 1737 - 1739
[2] Chinese Chemical Letters, 2013, vol. 24, # 8, p. 673 - 676
[3] Patent: WO2015/137750, 2015, A1. Location in patent: Paragraph 1245; 1246
[4] Organometallics, 2013, vol. 32, # 11, p. 3220 - 3226
[5] Synlett, 1999, # 11, p. 1763 - 1765

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