Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Chemical Reagents >  Organic reagents >  Acyl halide >  5-Amino-2,4,6-triiodoisophthaloyl dichloride

5-Amino-2,4,6-triiodoisophthaloyl dichloride

Basic information Safety Supplier Related

5-Amino-2,4,6-triiodoisophthaloyl dichloride Basic information

Product Name:
5-Amino-2,4,6-triiodoisophthaloyl dichloride
Synonyms:
  • 5-amino-2,4,6-triodoisophthalolylchloride
  • 5-amino-2,4,6- triiodisophthaloyl acid dichloride
  • 5-AMINO-2,4,6-TRIIODO-ISOPHTALOYL DICHLORIDE
  • 5-AMINO-2,4,6-TRIIODOISOPHTHALOYL DICHLORIDE
  • 5-Amino-2,4,6-Triiodoiso Phthaloyl Chloride
  • 5-Amino-2,4,6-triiodisophthaloyl dichloride
  • 5-Amino-2,4,6-Triiodo-1,3-Benzenedicarboxylic Acid Dichloride
  • 5-Amino-2,4,6-triiodoisophthaloydichloride
CAS:
37441-29-5
MF:
C8H2Cl2I3NO2
MW:
595.73
EINECS:
417-220-1
Product Categories:
  • Intermediate of Ioversol
Mol File:
37441-29-5.mol
More
Less

5-Amino-2,4,6-triiodoisophthaloyl dichloride Chemical Properties

Melting point:
231°C(lit.)
Boiling point:
566.9±50.0 °C(Predicted)
Density 
2.826±0.06 g/cm3(Predicted)
vapor pressure 
0.018Pa at 20℃
storage temp. 
Refrigerator, under inert atmosphere
solubility 
Acetone (Slightly), Methanol (Very Slightly)
pka
-3.45±0.10(Predicted)
form 
Solid
color 
Yellow toDark Brown
λmax
233nm(MeOH)(lit.)
LogP
3.7 at 20℃
CAS DataBase Reference
37441-29-5(CAS DataBase Reference)
More
Less

Safety Information

Hazard Codes 
Xi,N
Risk Statements 
43-51/53
Safety Statements 
22-36/37-61
RIDADR 
3077
HS Code 
2922.49.3700
HazardClass 
9
PackingGroup 
III
More
Less

5-Amino-2,4,6-triiodoisophthaloyl dichloride Usage And Synthesis

Description

5-Amino-2,4,6-triiodoisophthaloyl dichloride is a triiodinated compound that has been shown to bind to the receptor for asialoglycoprotein. It is used in the diagnosis of liver and kidney diseases. 5-Amino-2,4,6-triiodisophthaloyl acid dichloride is taken up by tissues and organs and causes damage to these tissues. The chloride ion binds to the molecule, making it more water soluble. The lactobionic acid residue is then cleaved off by an enzyme in the cell called beta-galactosidase. This leaves a molecule containing iodine which can be detected with a diagnostic technique such as X-ray crystallography or nuclear magnetic resonance spectroscopy.

Chemical Properties

Yellow Solid

Uses

5-Amino-2,4,6- triiodisophthaloyl acid dichloride is used in the preparation of trimeric X-ray contrast agents.

Preparation

5-Amino-2,4,6-triiodo-isophtalic acid (30 g, 0.054 mol), thionyl chloride (8.2 ml, 0.113 mol) and pyridine (0.2 ml) in 1 ,2 dichloroethane (20 ml) were heated to 70 ℃. A portion of thionyl chloride (15.2 ml, 0.21 mol) was added dropwise during 2 h, and the mixture was heated to 85 ℃ for 6 h. After cooling the reaction mixture to room temperature, it was poured into 300 g of ice-water. The yellow precipitate was filtered off, sucked dry and then washed with water until pH=5. The filter cake was then dried in a vacuum oven for 3 hrs. A light yellow powder was obtained as 5-Amino-2,4,6-triiodisophthaloyl acid dichloride.

Flammability and Explosibility

Not classified

5-Amino-2,4,6-triiodoisophthaloyl dichloride Preparation Products And Raw materials

Raw materials

5-Amino-2,4,6-triiodoisophthaloyl dichlorideSupplier

Jiangsu Yutian pharmaceutical Co.,Ltd. Gold
Tel
0518-86098000 18861350683
Email
lfan@jsytsw.com
ZHEJIANG HICHIPHARMACEUTICALCORPORATION LIMITED Gold
Tel
15715702293
Email
huangjs@hichipharm.com
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Email
Sales-CN@TCIchemicals.com
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18934348241
Email
sales4.gd@hwrkchemical.com