5-Amino-2,4,6-triiodoisophthaloyl dichloride Chemical Properties

Melting point:

231°C(lit.)

Boiling point:

566.9±50.0 °C(Predicted)

Density 

2.826±0.06 g/cm3(Predicted)

vapor pressure 

0.018Pa at 20℃

storage temp. 

Refrigerator, under inert atmosphere

solubility 

Acetone (Slightly), Methanol (Very Slightly)

pka

-3.45±0.10(Predicted)

form 

Solid

color 

Yellow toDark Brown

λmax

233nm(MeOH)(lit.)

LogP

3.7 at 20℃

CAS DataBase Reference

37441-29-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,N

Risk Statements 

43-51/53

Safety Statements 

22-36/37-61

RIDADR 

3077

HS Code 

2922.49.3700

HazardClass 

9

PackingGroup 

III

5-Amino-2,4,6-triiodoisophthaloyl dichloride Usage And Synthesis

Description

5-Amino-2,4,6-triiodoisophthaloyl dichloride is a triiodinated compound that has been shown to bind to the receptor for asialoglycoprotein. It is used in the diagnosis of liver and kidney diseases. 5-Amino-2,4,6-triiodisophthaloyl acid dichloride is taken up by tissues and organs and causes damage to these tissues. The chloride ion binds to the molecule, making it more water soluble. The lactobionic acid residue is then cleaved off by an enzyme in the cell called beta-galactosidase. This leaves a molecule containing iodine which can be detected with a diagnostic technique such as X-ray crystallography or nuclear magnetic resonance spectroscopy.

Chemical Properties

Yellow Solid

Uses

5-Amino-2,4,6- triiodisophthaloyl acid dichloride is used in the preparation of trimeric X-ray contrast agents.

Preparation

5-Amino-2,4,6-triiodo-isophtalic acid (30 g, 0.054 mol), thionyl chloride (8.2 ml, 0.113 mol) and pyridine (0.2 ml) in 1 ,2 dichloroethane (20 ml) were heated to 70 ℃. A portion of thionyl chloride (15.2 ml, 0.21 mol) was added dropwise during 2 h, and the mixture was heated to 85 ℃ for 6 h. After cooling the reaction mixture to room temperature, it was poured into 300 g of ice-water. The yellow precipitate was filtered off, sucked dry and then washed with water until pH=5. The filter cake was then dried in a vacuum oven for 3 hrs. A light yellow powder was obtained as 5-Amino-2,4,6-triiodisophthaloyl acid dichloride.

Flammability and Explosibility

Not classified

5-Amino-2,4,6-triiodoisophthaloyl dichloride(37441-29-5)Related Product Information

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