ZONIPORIDE
ZONIPORIDE Basic information
- Product Name:
- ZONIPORIDE
- Synonyms:
-
- N-[5-Cyclopropyl-1-(quinolin-5-yl)-1H-pyrazole-4-carbonyl]guanidine
- CP 597396
- ZONIPORIDE
- N-(Aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide hydrochloride hydrate
- Zoniporide hydrochloride hydrate
- 1H-Pyrazole-4-carboxamide, N-(aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-
- N-carbamimidoyl-5-cyclopropyl-1-(5-quinolyl)pyrazole-4-carboxamide
- CAS:
- 241800-98-6
- MF:
- C17H16N6O
- MW:
- 320.35
- Mol File:
- 241800-98-6.mol
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ZONIPORIDE Chemical Properties
- Density
- 1.54
- storage temp.
- 2-8°C
- solubility
- H2O: soluble2mg/mL, clear (warmed)
- form
- powder
- pka
- 11.44±0.46(Predicted)
- color
- white to tan
- Water Solubility
- H2O: 2mg/mL, clear (warmed)
- InChI
- 1S/C17H16N6O.ClH.H2O/c18-17(19)22-16(24)12-9-21-23(15(12)10-6-7-10)14-5-1-4-13-11(14)3-2-8-20-13;;/h1-5,8-10H,6-7H2,(H4,18,19,22,24);1H;1H2
- InChIKey
- UCIJUEGJEFJRMP-UHFFFAOYSA-N
- SMILES
- O.Cl.NC(=N)NC(=O)c1cnn(-c2cccc3ncccc23)c1C4CC4
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ZONIPORIDE Usage And Synthesis
Uses
Zoniporide hydrochloride hydrate has been used for the inhibition of sodium-hydrogen exchanger isoform 1 (NHE-1) in rat models. It has also been used in cytotoxicity assay and to study its effect on lymphocytic choriomeningitis virus multiplication.
Biochem/physiol Actions
Zoniporide is a potent and selective inhibitor of Na+/H+ exchanger isoform 1 (NHE-1). IC50 = 59 nM at NHE-1, vs. 12,000 nM at NHE-2; Zoniporide inhibits NHE-1-dependent Na+ update with IC50 of 14 nM.
ZONIPORIDESupplier
Sigma-Aldrich
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