8-METHYL-2,4-DICHLOROQUINAZOLINE Chemical Properties

Boiling point:

292℃

Density 

1.418

Flash point:

158℃

storage temp. 

Inert atmosphere,Room Temperature

pka

-0.20±0.30(Predicted)

Appearance

White to light yellow Solid

8-METHYL-2,4-DICHLOROQUINAZOLINE Usage And Synthesis

Synthesis

The general procedure for the synthesis of 2,4-dichloro-8-methylquinazoline from 2,4-dihydroxy-8-methylquinazoline was as follows: 8-methylquinazoline-2,4(1H,3H)-dione (4.50 g, 25.50 mmol) was added to phosphorochloridic acid (47.6 mL, 510.9 mmol). The reaction mixture was stirred at 100 °C for 6 h and subsequently cooled to room temperature. The reaction solution was slowly poured into water (300 mL) and the internal temperature was controlled to be below 60°C. After precipitating the solid, the product was collected by filtration to afford 2,4-dichloro-8-methylquinazoline (4.30 g, 79% yield).

References

[1] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 3, p. 254 - 259
[2] Patent: US5064833, 1991, A
[3] Patent: EP322133, 1991, B1
[4] Patent: EP322133, 1989, A1
[5] Synthesis (Germany), 2016, vol. 48, # 8, p. 1226 - 1234

8-METHYL-2,4-DICHLOROQUINAZOLINE(39576-83-5)Related Product Information

• Chlorotrimethylsilane
• Dichloroethane
• CHLOROETHANE
• Xylene
• 2,4-dichloro-8-(trifluoromethoxy)quinazoline
• 2,4-DICHLORO-7-BROMOQUINAZOLINE
• 2,4-DICHLORO-1,2,3,4-TETRAHYDRO-7-METHYLQUINAZOLINE
• 2,4-Dichloroquinazoline