(3,3-DIFLUOROCYCLOBUTYL)METHANOL Chemical Properties

Boiling point:

130.9±10.0 °C(Predicted)

Density 

1.2g/ml

refractive index 

1.40

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

clear liquid

pka

15.05±0.10(Predicted)

color 

Colorless to Almost colorless

InChI

InChI=1S/C5H8F2O/c6-5(7)1-4(2-5)3-8/h4,8H,1-3H2

InChIKey

MDZKTVVUZBIKGI-UHFFFAOYSA-N

SMILES

C1(CO)CC(F)(F)C1

Safety Information

HS Code 

2905599890

(3,3-DIFLUOROCYCLOBUTYL)METHANOL Usage And Synthesis

Uses

(3,3-Difluorocyclobutyl)methanol is an intermediate used to prepare diaminoalkane aspartic protease inhibitors.

Synthesis

Step 1: Synthesis of (3,3-difluorocyclobutyl)methanol Sodium borohydride (0.556 g, 14.70 mmol) was suspended in tetrahydrofuran (50 mL) and cooled to 0 °C. The methanol was then added to the mixture of sodium borohydride (0.556 g, 14.70 mmol). Subsequently, a solution of 3,3-difluorocyclobutanecarboxylic acid (2 g, 14.70 mmol) in tetrahydrofuran (50 mL) was added dropwise. After the dropwise addition, the reaction flask was removed from the ice bath and the reaction was stirred for 1 hour at room temperature. After that, the reaction mixture was cooled again to 0 °C and boron trifluoride-ether compound (1.862 mL, 14.70 mmol) was slowly added. The reaction was stirred at 0 °C overnight and gradually warmed up to room temperature. After completion of the reaction, the mixture was cooled again to 0 °C and the reaction was quenched with 95% ethanol (25 mL). After stirring in an ice bath for 1 h, the mixture was concentrated in vacuum. The residue was partitioned with dichloromethane and saturated saline and the organic phase was separated. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo to afford the title compound (3,3-difluorocyclobutyl) methanol as a light tan oil (1.629 g, 9% yield). 1H NMR (300 MHz, CDCl3) δ: 2.31-2.38 (m, 3H), 2.60-2.66 (m, 2H), 3.67 (m, 2H); MS (DCI) m/z: 123 (M+H)+.

References

[1] Patent: WO2015/112445, 2015, A1. Location in patent: Page/Page column 162; 163
[2] Patent: US2016/376240, 2016, A1. Location in patent: Paragraph 0683
[3] Patent: WO2012/7869, 2012, A2. Location in patent: Page/Page column 85
[4] Patent: US2012/10183, 2012, A1. Location in patent: Page/Page column 40
[5] Patent: US2009/105306, 2009, A1. Location in patent: Page/Page column 32

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