3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol CAS#: 164658-13-3

ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > 3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol

3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol

Basic information Safety Supplier Related

3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol Basic information

Product Name:

3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol

Synonyms:

3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol
CGP 60474
CS-506
3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol
CGP-60474;CGP 60474
1-Propanol, 3-[[4-[2-[(3-chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-
3-((4-(2-((3-Chlorophenyl)amino)pyrimidin-4-yl)pyridin-2-yl)amino)propan-1-ol
CGP60474, 10 mM in DMSO

CAS:

164658-13-3

MF:

C18H18ClN5O

MW:

355.82

EINECS:

200-258-5

Mol File:

164658-13-3.mol

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3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol Chemical Properties

Melting point:: 144-147℃
Boiling point:: 630.6±65.0 °C(Predicted)
Density: 1.356
storage temp.: 2-8°C(protect from light)
solubility: Soluble in DMSO
form: Powder
pka: 14.93±0.10(Predicted)
color: Light yellow to yellow

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3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol Usage And Synthesis

Uses

CGP 60474 is type of protein kinase C inhibitor (ckd1/cdk2) used in the treatment of different cancers

Definition

ChEBI: 3-[[4-[2-(3-chloroanilino)-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol is a substituted aniline.

in vivo

CGP-60474 (10?mg/kg; i.p.) inhibits the IL-6 level and increases the survival rate in the LPS endotoxemia model^[2].

Animal Model:	C57Bl/6 mice (LPS endotoxemia model)^[2]
Dosage:	10?mg/kg
Administration:	I.p.
Result:	Had a higher survival rate.

IC 50

CDK1-Cyclin B: 26 nM (IC₅₀); CDK2/cyclinE: 3 nM (IC₅₀); cdk2/cyclin A: 4 nM (IC₅₀); CDK4/cyclin D: 216 nM (IC₅₀); Cdk5/p25: 10 nM (IC₅₀); CDK7/cyclin H: 200 nM (IC₅₀); CDK9/cycT: 13 nM (IC₅₀); PKC

storage

Store at -20°C

3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanolSupplier

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