ChemicalBook > Product Catalog > Biochemical Engineering > Amino Acids and Derivatives > 4-Ethynyl-L-phenylalanine HCl
4-Ethynyl-L-phenylalanine HCl
4-Ethynyl-L-phenylalanine HCl Basic information
- Product Name:
- 4-Ethynyl-L-phenylalanine HCl
- Synonyms:
-
- L-Phenylalanine, 4-ethynyl-
- 4-Ethynyl-L-phenylalanine HCl
- 4-Ethynyl-L-phenylalanine
- 4-Ethynylphenylalanine
- pEthynylphenylalanine,p Ethynylphenylalanine
- (2S)-2-amino-3-(4-ethynylphenyl)propanoic acid
- (S)-2-Amino-3-(4-ethynylphenyl)propanoic acid
- p-Ethynylphenylalanine, 10 mM in DMSO
- CAS:
- 278605-15-5
- MF:
- C11H11NO2
- MW:
- 189.21
- Mol File:
- 278605-15-5.mol
More
Less
4-Ethynyl-L-phenylalanine HCl Chemical Properties
- Boiling point:
- 343.2±37.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 2.22 mg/mL (11.73 mM)
- form
- Solid
- pka
- 2.18±0.10(Predicted)
- color
- Off-white to light yellow
More
Less
4-Ethynyl-L-phenylalanine HCl Usage And Synthesis
Uses
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM[1]. p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
in vivo
p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1].
p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase[1].
| Animal Model: | Male Sprague-Dawley rats (200 g)[1] |
| Dosage: | 30 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Decreased in 5-HT and 5-HIAA levels in the rat midbrain. |
References
[1] Stokes AH, et al. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. J Neurochem. 2000 May;74(5):2067-73. DOI:10.1046/j.1471-4159.2000.0742067.x
4-Ethynyl-L-phenylalanine HClSupplier
Amatek Scientific Co. Ltd.
- Tel
- 0512-56316828 4008675858
- sales@amateksci.com
Amadis Chemical Company Limited
- Tel
- 571-89925085
- sales@amadischem.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
Advanced chemblocks inc
- Tel
- 650-6922368
- sales@achemblock.com
Beijing Jin Ming Biotechnology Co., Ltd.
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com