ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > protein tyrosine kinase > LDC1267
LDC1267
LDC1267 Basic information
- Product Name:
- LDC1267
- Synonyms:
-
- LDC1267
- N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-4-ethoxy-1-(4-fluoro-2-methyl-phenyl)pyrazole-3-carboxamide
- N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide
- CS-1641
- LDC 1267;LDC-1267
- 1H-Pyrazole-3-carboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-
- LDC1267 USP/EP/BP
- N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide
- CAS:
- 1361030-48-9
- MF:
- C30H26F2N4O5
- MW:
- 560.55
- Product Categories:
-
- Inhibitors
- Mol File:
- 1361030-48-9.mol
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LDC1267 Chemical Properties
- Boiling point:
- 628.4±55.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥20.75 mg/mL in DMSO
- form
- solid
- pka
- 9.36±0.70(Predicted)
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LDC1267 Usage And Synthesis
Biological Activity
LDC1267 is a highly selective TAM kinase inhibitor with IC50s of <5 nM, 8 nM, and 29 nM for Mer, Tyro3, and Axl, respectively. Low activity against Met, Aurora B, Lck, Src, and CDK8.
in vitro
LDC1267 moderately affected proliferation in 11 of 95 different cell lines with IC50 >5 μM. In NKG2D-activated NK cells, it abrogates the inhibitory effect of Gas6 stimulation.
in vivo
In B16F10 melanoma-bearing mice, LDC1267 (20 mg/kg, ip) potently enhanced anti-metastatic NK cell activity and resisted tumor metabolism without severe cytotoxicity.
target
| Target | Value |
| Mer (Cell-free assay) | <5 nM |
| Tyro3 (Cell-free assay) | 8 nM |
| Axl (Cell-free assay) | 29 nM |
LDC1267Supplier
Wuhan Topule Gold
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- +86-02787215551 +86-19945035818
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Shanghai Boyle Chemical Co., Ltd.
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- sales@boylechem.com
Dalian Meilun Biotech Co., Ltd.
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- 0411-62910999 13889544652
- sales@meilune.com
Haoyuan Chemexpress Co., Ltd.
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- 021-58950125
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AdooQ BioScience, LLC
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