D-PYR-D-PHE-D-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2
D-PYR-D-PHE-D-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2 Basic information
- Product Name:
- D-PYR-D-PHE-D-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2
- Synonyms:
-
- (D-PYR1,D-PHE2,D-TRP3,6)-GONADOTROPIN-RELEASING HORMONE
- (D-PYR1,D-PHE2,D-TRP3,6)-LHRH
- [D-PYR1, D-PHE2, D-TRP3,6]-LH-RH (HUMAN)
- (D-PYR1,D-PHE2,D-TRP3,6)-LUTEINIZING HORMONE-RELEASING FACTOR
- (D-PYR1,D-PHE2,D-TRP3,6)-LUTEINIZING HORMONE-RELEASING HORMONE
- [D-PYR1, D-PHE2, D-TRP3,6]-LUTEINIZING HORMONE-RELEASING HORMONE (HUMAN)
- D-PYR-D-PHE-D-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2
- [D-PYROGLU1,D-PHE2,D-TRP3,6]-LH-RH
- CAS:
- 68059-94-9
- MF:
- C67H84N16O13
- MW:
- 1321.48
- Product Categories:
-
- LH-RH
- Peptides for Cell Biology
- Releasing Factors
- Mol File:
- 68059-94-9.mol
D-PYR-D-PHE-D-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2 Chemical Properties
- storage temp.
- −20°C
Safety Information
- Hazard Codes
- T
- Risk Statements
- 60
- Safety Statements
- 53-22-36/37/39-45
- WGK Germany
- 3
MSDS
- Language:English Provider:SigmaAldrich
D-PYR-D-PHE-D-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2 Usage And Synthesis
Uses
[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH acts as a GnRH receptor antagonist[1].
in vivo
[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH (1.25 and 2.5 mg, subcutaneous injection, b.i.d, for 7 days) prolongs pregnancy in rats[1].
[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH (250 μg) inhibits ovulation by 100% in rats[2].
References
[1] Rivier C, et al. Effect of the LRF-antagonist [D-pGlu1, D-Phe2, D-Trp3,6]-LRF on pregnancy in the rat. Contraception. 1979 Feb;19(2):185-90. DOI:10.1016/s0010-7824(79)80030-x
[2] Rivier JE, et al. A potent luteinizing hormone releasing factor antagonist in vitro and inhibitor of ovulation in the rat. Life Sci. 1978 Aug 28;23(8):869-76. DOI:10.1016/0024-3205(78)90522-2
[3] Hsueh AJ, et al. Effect on an antagonistic analog of gonadotropin releasing hormone upon ovarian granulosa cell function. Life Sci. 1979 Oct 1;25(14):1223-9. DOI:10.1016/0024-3205(79)90464-8
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