DL-GLUTAMIC-2,4,4-D3 ACID Chemical Properties

Melting point:

185 °C (dec)(lit.)

storage temp. 

-20°C Freezer, Under inert atmosphere

solubility 

DMSO (Slightly, Heated), Water (Slightly)

form 

Solid

color 

White to Off-White

Appearance

white solid

CAS Number Unlabeled

617-65-2

DL-GLUTAMIC-2,4,4-D3 ACID Usage And Synthesis

Description

Glutamic acid together with its γ-monoamide – glutamine – makes up about a third of all free amino acids in blood plasma, its content in body proteins is 20-25 %. In the blood, glutamic acid maintains pH balance, binds excess ammonia, turning into glutamine, transports it to the site of detoxification, and serves as a reserve of amino groups. Glutamic acid acts as an excitatory neurotransmitter and agonist of all subtypes of glutamate receptors (metabotropic, kainate, NMDA and AMPA), and is also a precursor of gamma-aminobutyric acid (GABA). Glutamic acid has an immunomodulatory effect and affects many metabolic processes.

Uses

DL-Glutamic acid-d3 is the deuterium labeled DL-Glutamic acid. DL-Glutamic acid is the conjugate acid of Glutamic acid, which acts as a fundamental metabolite. Comparing with the second phase of polymorphs α and β L-Glutamic acid, DL-Glutamic acid presents better stability[1].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110

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