Paramethasone Chemical Properties

Melting point:

228-241°C

Boiling point:

573.5±50.0 °C(Predicted)

Density 

1.32±0.1 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

12.34±0.70(Predicted)

color 

White to Pale Beige

CAS DataBase Reference

53-33-8

Safety Information

Hazardous Substances Data

53-33-8(Hazardous Substances Data)

MSDS

• Language:English Provider:6a-Fluoro-11b,17a,21-trihydroxy-16a-methyl-1,4-pregnadiene-3,20-dione

Paramethasone Usage And Synthesis

Originator

Haldrone,Lilly,US,1961

Uses

Paramethasone, is a fluorinated glucocorticoid, having anti-inflammatory and immunosuppressant properties.

Uses

Glucocorticoid.

Definition

ChEBI: Paramethasone is a fluorinated steroid.

Manufacturing Process

A solution of 0.144 g of the 3-ethylene glycol ketal of 5α,11β,17α,21 tetrahydroxy-6β-fluoro-16α-methylallopregnane-3,20-dione-21 acetate in 12 ml of chloroform and 0.1 ml of absolute alcohol was cooled to -10°C in an icesalt bath and a stream of anhydrous hydrochloric acid was gently bubbled through the solution for 2.5 hours while the temperature was maintained between -5°C and -15°C. The solution was then diluted with 25 ml of chloroform, washed with dilute sodium bicarbonate and water, dried over anhydrous sodium sulfate, and evaporated to dryness under reduced pressure at 60°C or less to give 6α-fluoro-11β,17α,21-trihydroxy-16α-methyl-4-pregnene3,20-dione 21-acetate.

brand name

Haldrone (Lilly).

Therapeutic Function

Glucocorticoid

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