IDO-IN-3 Chemical Properties

Boiling point:

570.8±60.0 °C(Predicted)

Density 

1.86±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Ethanol: 1 mg/ml

form 

A crystalline solid

pka

7?+-.0.69(Predicted)

color 

White to off-white

IDO-IN-3 Usage And Synthesis

Description

IDO-IN-3 is an inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1; IC₅₀s = 290 and 98 nM for the human recombinant enzyme in a cell-free assay and in HeLa cells, respectively).

Uses

IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 290 nM.

IC 50

IDO: 290 nM (IC₅₀); IDO: 98 nM (IC₅₀, in HeLa cell)

References

[1] Yue EW, et al. INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology. ACS Med Chem Lett. 2017 Mar 6;8(5):486-491. DOI:10.1021/acsmedchemlett.6b00391

IDO-IN-3(2070018-30-1)Related Product Information

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