8-Nitrotryptanthrin Chemical Properties

Melting point:

>250 °C

Boiling point:

551.2±52.0 °C(Predicted)

Density 

1.67±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

DMSO:4.2(Max Conc. mg/mL);14.32(Max Conc. mM)

form 

A crystalline solid

pka

-7.55±0.20(Predicted)

color 

White to off-white

8-Nitrotryptanthrin Usage And Synthesis

Uses

GNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM.

IC 50

rhIDO2: 1.8 μM (IC₅₀); rhIDO2: 0.97 μM (Ki)

References

[1] Li J, et al. Establishment of a human indoleamine 2, 3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors. Eur J Med Chem. 2016 Nov 10;123:171-9. DOI:10.1016/j.ejmech.2016.07.013
[2] Scovill J, et al. Antitrypanosomal activities of tryptanthrins. Antimicrob Agents Chemother. 2002 Mar;46(3):882-3. DOI:10.1128/AAC.46.3.882-883.2002
[3] Hwang JM, et al. Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents. J Nat Prod. 2013 Mar 22;76(3):354-67. DOI:10.1021/np3007167

8-Nitrotryptanthrin(77603-42-0)Related Product Information

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