PT-2385
PT-2385 Basic information
- Product Name:
- PT-2385
- Synonyms:
-
- CS-2108
- PT 2385;PT-2385
- PT-2385
- Benzonitrile, 3-[[(1S)-2,2-difluoro-2,3-dihydro-1-hydroxy-7-(methylsulfonyl)-1H-inden-4-yl]oxy]-5-fluoro-
- (S)-3-(2,2-Difluoro-1-hydroxy-7-methanesulfonyl-indan-4-yloxy)-5-fluoro-benzonitrile
- (S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile
- Inhibitor,inhibit,Hypoxia-inducible factors,HIF/HIF Prolyl-Hydroxylase,HIF-PH,PT 2385,HIFs,PT-2385,PT2385
- (methylsulfonyl)
- CAS:
- 1672665-49-4
- MF:
- C17H12F3NO4S
- MW:
- 383.34
- Mol File:
- 1672665-49-4.mol
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PT-2385 Chemical Properties
- Boiling point:
- 524.7±50.0 °C(Predicted)
- Density
- 1.57±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO:50.0(Max Conc. mg/mL);130.43(Max Conc. mM)
- pka
- 11.28±0.40(Predicted)
- form
- Solid
- color
- White to off-white
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PT-2385 Usage And Synthesis
Uses
PT2385 is a HIF-2α antagonist with EC50 of 27 nM in the luciferase assay, with no apparent off-target effects.
in vivo
PT-2385 (30 or 100 mg/kg; oral gavage; twice daily) result in a rapid, dose-dependent tumor regression[3].
PT-2385 (PT2385) inhibits expression of HIF-2α regulated genes in a dose dependent manner in vivo. Tumor is regressed with PT-2385 (3 and 10 mg/kg, p.o., b.i.d. dose) in 786-O xenograft. PT-2385 (1,3 and 10 mg/kg) also inhibits tumor-derived VEGFA protein levels. PT-2385 (10 mg/kg) treatment reduces proliferation (Ki67) and angiogenesis (CD-31)[1].
| Animal Model: | SCID/beige mice with the 786-O and A498 RCC cell lines[3] |
| Dosage: | 30 or 100 mg/kg |
| Administration: | Oral gavage; twice daily |
| Result: | Resulted in a rapid, dose-dependent tumor regression. |
PT-2385Supplier
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
JW & Y Pharmlab Co., Ltd.
- Tel
- 021-64340559 13651849907;
- xinyu_shi@jwypharmlab.com.cn
Guangzhou QiYun Biotechnology Co., Ltd.
- Tel
- 020-61288194 61288195
- 505721671@qq.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com