GlyT2-IN-1 Chemical Properties

Melting point:

136 - 138°C

Boiling point:

538.4±60.0 °C(Predicted)

Density 

1.58±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO (Slightly), Methanol (Very Slightly)

form 

powder

pka

-1.32±0.10(Predicted)

color 

white to beige

InChI

1S/C13H8Cl2N4S2/c14-9-2-1-3-10(15)8(9)7-20-13-19-18-12(21-13)11-6-16-4-5-17-11/h1-6H,7H2

InChIKey

BQNXBSYSQXSXPT-UHFFFAOYSA-N

SMILES

[s]1c(nnc1c3nccnc3)SCc2c(cccc2Cl)Cl

Safety Information

WGK Germany 

WGK 3

HS Code 

2934999090

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

GlyT2-IN-1 Usage And Synthesis

Uses

Yoda 1 is a piezo1 channel activator, sensitizes piezo1 to activation by pressure and slows the inactivation phase of transient currents in human embryonic kidney (HEK) cells.

Definition

ChEBI: Yoda 1 is a member of the class of thiadiazoles that is 1,3,4-thiadiazole substituted by pyrazin-2-yl and (2,6-dichlorobenzyl)sulfanediyl groups at positions 2 and 5, respectively. It is a selective activator of mechanosensitive channel piezo1. It has a role as a glycine transporter 2 inhibitor and a piezo1 agonist. It is an aromatic compound, a member of pyrazines, a member of thiadiazoles, an organic sulfide and a dichlorobenzene.

General Description

Yoda1 is a novel synthetic small molecule developed to study the kinetics, regulation and function of the cation channel Piezo-type mechanosensitive ion channel component 1 (Piezo1).

Biochem/physiol Actions

Yoda1 is a specific activator of mouse and human cation channel Piezo1, a mechanosensitive channel that mediates Ca2+ influx on mechanical activation and has been linked to a role in blood vessel development. Yoda1 stabilizes the Piezo1 open channel. In red blood cells, this was followed by downstream activation of the KCa3.1 Gardos channel with resultant calcium influx and potassium and water efflux, causing shrinkage of the cells. Yoda1 is the first Piezo1 agonist, giving the first evidence of non-mechanical activation of a Piezo channel.

storage

Store at +4°C