ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > ETC-159
ETC-159
ETC-159 Basic information
- Product Name:
- ETC-159
- Synonyms:
-
- ETC-159
- 1,2,3,6-Tetrahydro-1,3-dimethyl-2,6-dioxo-N-(6-phenyl-3-pyridazinyl)-7H-purine-7-acetamide
- 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(6-phenylpyridazin-3-yl)acetamide
- CS-1584
- ETC 1922159
- ETC-159;ETC 159;ETC159;ETC 1922159;ETC-1922159;ETC1922159
- ETC1922159
- ETC-1922159
- CAS:
- 1638250-96-0
- MF:
- C19H17N7O3
- MW:
- 391.38
- Mol File:
- 1638250-96-0.mol
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ETC-159 Chemical Properties
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 33 mg/ml; DMSO: 33 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml
- form
- A crystalline solid
- pka
- 11.28±0.70(Predicted)
- color
- White to off-white
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ETC-159 Usage And Synthesis
Uses
1,2,3,6-Tetrahydro-1,3-dimethyl-2,6-dioxo-N-(6-phenyl-3-pyridazinyl)-7H-purine-7-acetamide is a novel potent PORCN inhibitor that blocks the secretion and activity of all Wnts.
in vivo
ETC-159 inhibits mouse PORCN with an IC50 of 18.1 nM, whereas the IC50 for Xenopus Porcn is approximately four fold higher (70 nM). ETC-159 is remarkably effective in treating RSPO-translocation bearing colorectal cancer (CRC) patient-derived xenografts. ETC-159 exhibits good oral pharmacokinetics in mice allowing preclinical evaluation via oral administration. After a single oral dose of 5 mg/kg, ETC-159 is rapidly absorbed into the blood with a Tmax of ~0.5 h and oral bioavailability of 100%[1].
ETC-159Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
AdooQ Bioscience CHINA
- Tel
- 025-58849295 18951903616;
- info@adooq.cn
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266