Fluorescein-PEG3-(N-Boc)-Amine
Fluorescein-PEG3-(N-Boc)-Amine Basic information
- Product Name:
- Fluorescein-PEG3-(N-Boc)-Amine
- Synonyms:
-
- Fluorescein-PEG3-NHBoc
- Fluorescein-PEG3-(N-Boc)-Amine
- 5,8,11-Trioxa-2,14-diazapentadecanoic acid, 15-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)amino]-15-thioxo-, 1,1-dimethylethyl ester
- 5-FITC-PEG3-NHBoc
- 1,1-Dimethylethyl 15-[(3′,6′-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9′-[9H]xanthen]-5-yl)amino]-15-thioxo-5,8,11-trioxa-2,14-diazapentadecanoate
- CAS:
- 1807534-77-5
- MF:
- C34H39N3O10S
- MW:
- 681.75
- Mol File:
- 1807534-77-5.mol
Fluorescein-PEG3-(N-Boc)-Amine Chemical Properties
- Density
- 1.41±0.1 g/cm3(Predicted)
- solubility
- Soluble in DMF, Acetone, Methanol
- pka
- 9.33±0.20(Predicted)
Fluorescein-PEG3-(N-Boc)-Amine Usage And Synthesis
Description
Fluorescein-PEG3-(N-Boc)-amine is a heterobiofunctional PEG linker containing a fluorescein dye and a Boc-protected amine group, which can be regenerated by mild acidic conditions and then be reactive with cabroxylic acid, activated NHS ester, carbonyl (ketone, aldehyde) etc. Fluorescein is a common fluorescent tracer (494nm/521nm) for staining cells, tissues, biomarkers or nanoparticles and this reagent can be used to tag biomolecules and nanoparticles.
Uses
Fluorescein-PEG3-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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