3,5-DICHLORO-4-HYDROXYBENZALDEHYDE Chemical Properties

Melting point:

154 °C

Boiling point:

256.7±35.0 °C(Predicted)

Density 

1.547±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

solid

pka

4.85±0.23(Predicted)

color 

White

CAS DataBase Reference

2314-36-5

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

26

Hazard Note 

Irritant

HS Code 

2913000090

3,5-DICHLORO-4-HYDROXYBENZALDEHYDE Usage And Synthesis

Uses

3,5-Dichloro-4-hydroxybenzaldehyde (cas# 2314-36-5) is a useful research chemical. It is used in fluorescent dye, preparation method therefor and use thereof.

Synthesis

General procedure for the synthesis of 3,5-dichloro-4-hydroxybenzaldehyde from 2,6-dichloro-4-methylphenol: A mixture of the substrate 2,6-dichloro-4-methylphenol (1 mmol), cobalt salts (n1 mol%), and NaOH (n2 equiv.) in ethylene glycol (5 mL) was subjected to a stirring reaction under an atmosphere of oxygen (1 atm) at 80°C for 8 hours. Upon completion of the reaction, hydrochloric acid (10 mL, 2%) and methyl tert-butyl ether (MTBE, 10 mL) were sequentially added to the reaction mixture. The organic layer was separated and the aqueous phase was further extracted with MTBE (10 mL x 2). All organic phases were combined, dried with anhydrous sodium sulfate and concentrated to obtain the residue. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, 10:1, v/v) to afford the target product 3,5-dichloro-4-hydroxybenzaldehyde.

References

[1] Tetrahedron Letters, 2014, vol. 55, # 8, p. 1406 - 1411
[2] Green Chemistry, 2014, vol. 16, # 5, p. 2807 - 2814
[3] Green Chemistry, 2014, vol. 16, # 3, p. 1248 - 1254

3,5-DICHLORO-4-HYDROXYBENZALDEHYDE(2314-36-5)Related Product Information

• METHYL 3,5-DICHLORO-4-HYDROXYBENZOATE
• ETHYL 3,5-DICHLORO-4-HYDROXYBENZOATE
• 3,5-Dichloro-4-hydroxybenzoic acid
• 3,5-DICHLORO-4-PROPOXYBENZOIC ACID
• 2,3-Dichloro-4-hydroxybenzaldehyde 97%,2,3-DICHLORO-4-HYDROXYBENZALDEHYDE
• 3,5-DICHLORO-2-HYDROXYBENZALDEHYDE
• 4,6-DICHLORO-2-HYDROXYBENZALDEHYDE,2,4-DICHLORO-6-HYDROXYBENZALDEHYDE
• 3,5-DICHLORO-4-METHOXYBENZOIC ACID
• 3,5-DICHLORO-4-METHOXYBENZOIC ACID ETHYL ESTER
• 3,5-DICHLORO-4-HYDROXYBENZOIC ACID PROPYL ESTER
• 3,5-DICHLORO-4-HYDROXYBENZOHYDRAZIDE
• avilamycin A
• 1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone
• METHYL 3,5-DICHLORO-4-METHOXYBENZOATE
• 3',5'-DICHLORO-4'-HYDROXYACETOPHENONE
• 4-(BENZYLOXY)-3,5-DICHLOROBENZALDEHYDE
• 3,5-DICHLORO-4-METHOXYBENZENECARBOHYDRAZIDE
• 4-(Allyloxy)-3,5-dichlorobenzoic acid