Methyl 5-formyl-2-hydroxybenzoate Chemical Properties

Melting point:

79.0 to 83.0 °C

Boiling point:

294.5±25.0 °C(Predicted)

Density 

1.310±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

powder to crystal

pka

7.57±0.18(Predicted)

color 

White to Light yellow

InChI

InChI=1S/C9H8O4/c1-13-9(12)7-4-6(5-10)2-3-8(7)11/h2-5,11H,1H3

InChIKey

XJKWVPNWHOCFBR-UHFFFAOYSA-N

SMILES

C(OC)(=O)C1=CC(C=O)=CC=C1O

CAS DataBase Reference

41489-76-3

Safety Information

HS Code 

2916399090

Methyl 5-formyl-2-hydroxybenzoate Usage And Synthesis

Synthesis

5-Formyl-2-hydroxybenzoic acid (500 g, 30 mmol, Sigma-Aldrich) was used as a raw material, mixed with concentrated H2SO4 (200 mL) and methanol (50 mL), and the reaction was stirred under reflux conditions for 24 hours. After completion of the reaction, the mixture was concentrated under reduced pressure to give 536 g of methyl 5-formyl-2-hydroxybenzoate (compound of formula FO) as a colorless oil in 99% yield.

References

[1] Patent: WO2009/27820, 2009, A2. Location in patent: Page/Page column 232
[2] Patent: US2014/155391, 2014, A1. Location in patent: Paragraph 0632; 0633
[3] Journal of Organic Chemistry, 2017, vol. 82, # 16, p. 8580 - 8589
[4] Patent: EP2143710, 2010, A1. Location in patent: Page/Page column 29
[5] Patent: EP2332942, 2011, A1. Location in patent: Page/Page column 22

Methyl 5-formyl-2-hydroxybenzoate(41489-76-3)Related Product Information

• Methylparaben
• Methyl acrylate
• Methyl acetate
• METHYL 4-AMINOSALICYLATE
• Kresoxim-methyl
• ACETYLSALICYLIC ACID METHYL ESTER
• Methyl 5-chloro-2-hydroxybenzoate
• Bensulfuron methyl
• Methyl salicylate
• Thiophanate-methyl
• Methyl
• Parathion-methyl
• ETHYL 5-ACETYL-2-ETHOXYBENZOATE
• Methyl bromide
• METHYL 5-ACETYLSALICYLATE
• DIMETHYL 4-HYDROXYISOPHTHALATE
• 5-Formylsalicylic acid
• Formyl radical