BMS-986205 Chemical Properties

Boiling point:

606.8±45.0 °C(Predicted)

Density 

1?+-.0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO:42.0(Max Conc. mg/mL);73.75(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);175.59(Max Conc. mM)

pka

13.80±0.70(Predicted)

BMS-986205 Usage And Synthesis

Biological Activity

Linrodostat (BMS-986205, ONO-7701) is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptophan-2, 3-dioxygenase cell-based assays.

Description

BMS-986205, also known as Linrodostat, ONO-7701 and F001287, a potent and selective, orally active IDO1 inhibitor with potential immunomodulating and antineoplastic activities.

Uses

BMS-986205 is a compound being studied for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders.

BMS-986205(1923833-60-6)Related Product Information

• BMS 303141
• BMS813160
• 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-
• Insulin-like Growth Factor-1 Receptor Inhibitor
• PD-L1 inhibitor 1
• AC480 (BMS-599626)
• 3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo-N-(2-pyridinylmethyl)-5H-benzo[4,5]cyclohepta[1,2-b]pyridine-7-methanesulfonamide
• 2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID
• Upadacitinib
• Q-VD-OPh hydrate
• N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
• H3B-6527
• 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
• Senexin B
• COH-29
• (S)-4-(4-((2-(3,5-diMethylphenyl)pyrrolidin-1-yl)Methyl)phenoxy)-3-fluorobenzaMide
• Budiodarone tartrate
• 2-(2-((4-bromophenyl)amino)-2-oxoethoxy)-N-(2-(methyl(phenyl)amino)-2-oxoethyl)benzamide