BMS-986205 Chemical Properties

Boiling point:

606.8±45.0 °C(Predicted)

Density 

1?+-.0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO:42.0(Max Conc. mg/mL);73.75(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);175.59(Max Conc. mM)

form 

Solid

pka

13.80±0.70(Predicted)

color 

White to off-white

BMS-986205 Usage And Synthesis

Biological Activity

Linrodostat (BMS-986205, ONO-7701) is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptophan-2, 3-dioxygenase cell-based assays.

Description

BMS-986205, also known as Linrodostat, ONO-7701 and F001287, a potent and selective, orally active IDO1 inhibitor with potential immunomodulating and antineoplastic activities.

Uses

BMS-986205 is a compound being studied for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders.

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