BMS813160 Chemical Properties

Density 

1.31±0.1 g/cm3(Predicted)

storage temp. 

4°C, protect from light

solubility 

DMSO:61.0(Max Conc. mg/mL);125.86(Max Conc. mM)
Ethanol:97.0(Max Conc. mg/mL);200.14(Max Conc. mM)

form 

A crystalline solid

pka

15.46±0.60(Predicted)

BMS813160 Usage And Synthesis

Description

BMS 813160 is a dual antagonist of chemokine receptor 2 (CCR2) and CCR5 (IC₅₀s = 6.2 and 3.6 nM, respectively, in radioligand binding assays). It inhibits chemotaxis induced by the CCR2 ligand MCP-1 in THP-1 cells the CCR5 ligand MIP-1β in isolated peripheral T cells with IC₅₀ values of 0.8 and 1.1 nM, respectively. BMS 813160 inhibits peritoneal monocyte and macrophage infiltration in an hCCR-2 KI mouse model of thioglycolate-induced peritonitis, with 54% inhibition when administered at a dose of 50 mg/kg twice per day.

Uses

BMS-813160, a dual CCR2/CCR5 chemokine antagonist.

BMS813160(1286279-29-5)Related Product Information

• BMS-986020
• BMS-852927
• XL-652
• BMS-986142
• BMS 303141
• 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-
• Insulin-like Growth Factor-1 Receptor Inhibitor
• PD-L1 inhibitor 1
• AC480 (BMS-599626)
• BMS-986205