BMS813160 Chemical Properties

Density 

1.31±0.1 g/cm3(Predicted)

storage temp. 

4°C, protect from light

solubility 

DMSO:61.0(Max Conc. mg/mL);125.86(Max Conc. mM)
Ethanol:97.0(Max Conc. mg/mL);200.14(Max Conc. mM)

form 

A crystalline solid

pka

15.46±0.60(Predicted)

color 

White to off-white

BMS813160 Usage And Synthesis

Description

BMS 813160 is a dual antagonist of chemokine receptor 2 (CCR2) and CCR5 (IC₅₀s = 6.2 and 3.6 nM, respectively, in radioligand binding assays). It inhibits chemotaxis induced by the CCR2 ligand MCP-1 in THP-1 cells the CCR5 ligand MIP-1β in isolated peripheral T cells with IC₅₀ values of 0.8 and 1.1 nM, respectively. BMS 813160 inhibits peritoneal monocyte and macrophage infiltration in an hCCR-2 KI mouse model of thioglycolate-induced peritonitis, with 54% inhibition when administered at a dose of 50 mg/kg twice per day.

Uses

BMS-813160, a dual CCR2/CCR5 chemokine antagonist.

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