Propargyl-PEG5-CH2CO2-NHS Chemical Properties

storage temp. 

Storage temp. -20°C

solubility 

Soluble in DMSO, DCM, DMF

form 

Viscous Liquid

color 

Colorless to light brown

Propargyl-PEG5-CH2CO2-NHS Usage And Synthesis

Description

Propargyl-PEG5-CH2CO2-NHS is an amine reactive linker with an alkyne moeity which can react with azide-bearing biomolecules in copper catalyzed Click Chemistry reactions. The PEG units enhance the solubility of the linker in aqueous media.

Uses

Propargyl-PEG4-O-C1-NHS ester (compound 8) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-O-C1-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs; Alkyl/ether

References

[1] Kussrow A, et al. Measurement of monovalent and polyvalent carbohydrate-lectin binding by back-scatteringinterferometry. Anal Chem. 2009 Jun 15;81(12):4889-97. DOI:10.1021/ac900569c

Propargyl-PEG5-CH2CO2-NHS(1161883-51-7)Related Product Information

• 2-(prop-2-ynyloxy)acetic acid
• 2-(2-Propyn-1-yloxy)acetic acid tert-butyl ester
• Propargyl-PEG5-CH2CO2H
• Propargyl-PEG5-CH2CO2tBu