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3-Maleimidobenzoic acid N-hydroxysuccinimide ester

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3-Maleimidobenzoic acid N-hydroxysuccinimide ester Basic information

Product Name:
3-Maleimidobenzoic acid N-hydroxysuccinimide ester
Synonyms:
  • MBS
  • 3-MALEIMIDOBENZOIC ACID N-HYDROXYSUCCINIMIDE ESTER
  • 3-MALEIMIDOBENZOIC ACID N-SUCCINIMIDYL ESTER
  • 3-(2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-yl)benzoic acid 2,5-dioxopyrrolidine-1-yl ester
  • 3-(2,5-Dioxo-3-pyrroline-1-yl)benzoic acid succinimidyl ester
  • 3-(Maleimide-N-yl)benzoic acid succinimidyl ester
  • 3-[(2,5-Dioxo-2,5-dihydro-1H-pyrrole)-1-yl]benzoic acid 2,5-dioxo-1-pyrrolidinyl ester
  • Succinimidylmaleimidobenzoate
CAS:
58626-38-3
MF:
C15H10N2O6
MW:
314.25
EINECS:
261-368-8
Product Categories:
  • Nitric Oxide Reagents
  • N-Substituted Maleimides
  • N-Substituted Maleimides, Succinimides & Phthalimides
  • N-Substituted Succinimides
  • Cross Linking Reagents
  • Maleimide Derivatives
  • Cross Linking Reagents,Maleimide Derivatives
  • MTS & Sulfhydryl Active Reagents
  • Heterobifunctional Crosslinker
  • heteroXlink
Mol File:
58626-38-3.mol
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3-Maleimidobenzoic acid N-hydroxysuccinimide ester Chemical Properties

Melting point:
175-177 °C(lit.)
Boiling point:
524.5±52.0 °C(Predicted)
Density 
1.59±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
ethyl acetate or DMF: ≤20 mg/mL may require addition of solvent to coupling buffer to at least 5% to maintain solubility
form 
crystalline
pka
-2.63±0.20(Predicted)
color 
White to Almost white
Sensitive 
Moisture & Light Sensitive
BRN 
1505254
InChIKey
LLXVXPPXELIDGQ-UHFFFAOYSA-N
CAS DataBase Reference
58626-38-3(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
10-21
HS Code 
29280000

MSDS

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3-Maleimidobenzoic acid N-hydroxysuccinimide ester Usage And Synthesis

Description

MBS is a heterobifunction crosslinker that contains a maleimide group which is reactive towards sulfhydryls and an NHS ester, useful for targeting amine groups.

Chemical Properties

Crystalline

Uses

N-Succinimidyl 3-maleimidobenzoate is useful for forming enzyme immunoconjugates. It has a 9.9 Angstrom spacer arm. Heterobifunctional crosslinking reagent reactive toward primary amine and sulfhydryl. Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates

Uses

3-Maleimidobenzoic acid N-hydroxysuccinimide ester is a heterobifunctional coupling reagent useful for forming enzyme immunoconjugates. The reactive groups are the NHS ester and maeimide.

Biochem/physiol Actions

3-Maleimidobenzoic acid N-hydroxysuccinimide is used as a fixative for the preservation of pollen tube F-actin distribution. It imposes less damage when used on pollen tubes.

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