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18BETA(H)-OLEAN-12-EN-3-ONE

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18BETA(H)-OLEAN-12-EN-3-ONE Basic information

Product Name:
18BETA(H)-OLEAN-12-EN-3-ONE
Synonyms:
  • 18BETA(H)-OLEAN-12-EN-3-ONE
  • Olean-12-en-3-one
  • beta-Amyrone
  • 18(H)-Olean-12-en-3-one
  • (6aR,6bS,8aR,12aS,14aR,14bR)-4,4,6a,6b,8a,11,11,14b-octamethyl-2,4a,5,6,7,8,9,10,12,12a,14,14a-dodecahydro-1H-picen-3-one
  • β-Amyron
  • antifungal,AChE,COX-2,PI3K-Akt,Anti-inflammatory,Fungal,β-Amyrone,inflammation,CHIKV,Cyclooxygenase,inhibit,Inhibitor,infection,obesity,Peroxisome proliferator-activated receptors,COX,PPAR
  • (4aR,6aR,6bS,8aR,12aR,14aR,14bR)-4,4,6a,6b,8a,11,11,14b-Octamethyl-1,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-octadecahydropicen-3(2H)-one
CAS:
638-97-1
MF:
C30H48O
MW:
424.7
Mol File:
638-97-1.mol
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18BETA(H)-OLEAN-12-EN-3-ONE Chemical Properties

Melting point:
177-178 °C
Boiling point:
488.3±45.0 °C(Predicted)
Density 
1.01±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
form 
Solid
color 
White to off-white
InChIKey
LIIFBMGUDSHTOU-CFYIDONUSA-N
SMILES
C1(=O)[C@@]([C@]2([C@](C)(CC1)[C@]1([H])[C@@]([C@]3(C(=CC1)[C@]1([C@@](CC[C@](C1)(C)C)(C)CC3)[H])C)(C)CC2)[H])(C)C
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18BETA(H)-OLEAN-12-EN-3-ONE Usage And Synthesis

Uses

β-Amyron is used as inhibitor of cyclooxygenase and lipoxygenase enzymes to study the structure-activity relationships of pentacyclic triterpenoids.

in vivo

β-Amyrone (local administration on ear, 0.1-0.6 mg/kg, a single dose) inhibits ear edema formation in phenol-induced edema mice[1].

Animal Model:Ear phenol-induced edema in Balb C mice[1]
Dosage:0.1, 0.3, 0.6 mg/kg, a single dose
Administration:Local administration (20 L solution) on ear
Result:Inhibited ear edema formation in a dose-related manner (47% inhibition at the dose of 0.6mg/kg).

IC 50

COX-2

18BETA(H)-OLEAN-12-EN-3-ONESupplier

Shanghai Taopu Industrial Co., LTD Gold
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