3-Oxoolean-12-en-28-oic acid methyl ester Chemical Properties

Melting point:

184 °C

Boiling point:

523.9±50.0 °C(Predicted)

Density 

1.06±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

form 

Solid

color 

White to off-white

3-Oxoolean-12-en-28-oic acid methyl ester Usage And Synthesis

Uses

Methyl oleanonate is a natural triterpene PPARγ agonist isolated from the species of Pistacia lentiscus var. Chia[1]. Methyl oleanonate is a modified oleanolic acid derivative with anti-cancer effects[2].

IC 50

PPARγ

References

[1] Rasmus K Petersen, et al. Pharmacophore-driven identification of PPARγ agonists from natural sources. J Comput Aided Mol Des. 2011 Feb;25(2):107-16. DOI:10.1007/s10822-010-9398-5
[2] Barbara Bednarczyk-Cwynar, et al. Anticancer effect of A-ring or/and C-ring modified oleanolic acid derivatives on KB, MCF-7 and HeLa cell lines. Org Biomol Chem. 2012 Mar 21;10(11):2201-5 DOI:10.1039/c2ob06923g

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