N-Formylglycine Chemical Properties

Melting point:

149-151 °C

Boiling point:

193.26°C (rough estimate)

Density 

1.4873 (rough estimate)

refractive index 

1.4940 (estimate)

storage temp. 

2-8°C

solubility 

Methanol (Slightly), Water (Slightly)

form 

Solid

pka

pK1:3.43 (25°C)

color 

White

Water Solubility 

very faint turbidity

BRN 

1749108

CAS DataBase Reference

2491-15-8(CAS DataBase Reference)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

RTECS 

MC0547000

HS Code 

29241990

Toxicity

LD50 unreported in rat: > 3gm/kg

MSDS

• Language:English Provider:SigmaAldrich

N-Formylglycine Usage And Synthesis

Chemical Properties

White solid

Uses

N-Formylglycine is a simple dipeptide and a post-translationally generated residue with unique catalytic capabilities and biotechnology applications.

Definition

ChEBI: An N-acylglycine resulting from the formal condensation of the amino group of glycine with formic acid.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

The general procedure for the synthesis of 2-formamidoacetic acid from formic acid and glycine was as follows: formic acid (140 mL, 3.71 mol) was reacted with acetic anhydride (47 mL, 0.50 mol) with stirring for 1 hour at 45 °C. Subsequently, glycine (0.05 mol) was added to the reaction mixture and stirring was continued at room temperature for 24 hours. After completion of the reaction, the mixture was evaporated to dryness to afford the target product 2-formamidoacetic acid.

References

[1] Organic and Biomolecular Chemistry, 2015, vol. 14, # 1, p. 93 - 96
[2] Synthetic Communications, 1983, vol. 13, # 9, p. 745 - 752
[3] Organic Letters, 2018, vol. 20, # 18, p. 5877 - 5880
[4] Chemical Communications, 2012, vol. 48, # 31, p. 3775 - 3777
[5] Tetrahedron, 2013, vol. 69, # 43, p. 9161 - 9165

N-Formylglycine(2491-15-8)Related Product Information

• Benzoyl peroxide
• Sarcosine
• Glycine
• N-Formylmorpholine
• Caprylylglycine
• Calcium folinate
• N-FORMYL-L-METHIONINE
• Dibenzoylmethane
• N-Carbobenzyloxy-L-alanine
• Nalpha-Cbz-L-Arginine
• CHLOROACETYL-L-TYROSINE
• N-Cbz-L-Serine
• N-ACETYL-D-PHENYLALANINE
• Ethyl N-benzoyl-L-tyrosinate
• Dibenzoyltartaric acid
• H-GAMMA-GLU-GLU-OH
• N-(tert-Butoxycarbonyl)-L-phenylalanine
• Hippuric acid