2,4,5-TRIFLUOROBENZYL CHLORIDE Chemical Properties

Boiling point:

175℃

Density 

1,689 g/cm³

refractive index 

1.5050

Flash point:

65°C

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

clear liquid

color 

Colorless to Almost colorless

InChI

InChI=1S/C7H4ClF3/c8-3-4-1-6(10)7(11)2-5(4)9/h1-2H,3H2

InChIKey

JMXPOOVDUVHJRO-UHFFFAOYSA-N

SMILES

C1(CCl)=CC(F)=C(F)C=C1F

CAS DataBase Reference

243139-71-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

C,Xn

Risk Statements 

34-36/37/38-20/21/22

Safety Statements 

26-36/37/39-36

RIDADR 

3265

Hazard Note 

Corrosive

HazardClass 

8

PackingGroup 

II

HS Code 

2903998090

MSDS

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2,4,5-TRIFLUOROBENZYL CHLORIDE Usage And Synthesis

Chemical Properties

Colorless to Almost colorless clear liquid.

Uses

2,4,5-Trifluorobenzyl chloride is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor that decreases in glucagon to improve control of blood sugar used for the treatment of type 1 diabetes, 79% of the dose excreted in the urine.

Uses

2,4,5-Trifluorobenzyl chloride is a useful research chemical.

Synthesis

On the four-neck flask, install a stirrer, a thermometer, a chlorine gas pipe and a reflux condenser. The reflux condenser is connected to the HCl absorption system, and a light source is installed near the flask.Add 146.0g 2,4,5-trifluorotoluene and 3.0g azobisisobutyronitrile into the reaction flask, stir and heat, and when the temperature rises to 110°C, add dry chlorine gas, and Using GC tracking, after about 3h of chlorine gas, stop the halogenating agent chlorine gas, cool the reactant, wash it with water to neutrality, dry and distill under reduced pressure to obtain 2,4,5-trifluorobenzyl chloride.

2,4,5-TRIFLUOROBENZYL CHLORIDE(243139-71-1)Related Product Information

• Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
• Sitagliptin
• Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)-
• (R)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate
• Sitagliptin Impurity 34
• 2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE
• ethyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate
• Methyl 3-aMino-4-(2,4,5-trifluorophenyl)butanoate
• Sitagliptin impurity 5
• Sitagliptin Impurity 77
• Sitagliptin Impurity 28
• 2,2,2-TRIFLUORO-N'-(TRIFLUOROACETYL)ACETOHYDRAZIDE
• (S)-Sitagliptin Phosphate
• Sitagliptin DeaMino IMpurity 1
• Sitagliptin Defuoro IMpurity 5
• Sitagliptin Impurity 14
• (R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl)-6,7,10,11-tetrahydro-[1,2,4]triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione
• 2,4,5-Trifluorophenylacetic acid