2-HYDROXY-5-IODO-BENZONITRILE Chemical Properties

Melting point:

115-117℃

Boiling point:

321℃

Density 

2.09

Flash point:

148℃

storage temp. 

2-8°C, protect from light, stored under nitrogen

pka

6.55±0.18(Predicted)

Appearance

White to light yellow Solid

2-HYDROXY-5-IODO-BENZONITRILE Usage And Synthesis

Application

2-Hydroxy-5-iodobenzonitrile is an organic intermediate that can be used to prepare tert-butyl 4-((2-(aminomethyl)-4-iodophenoxy)methyl)piperidine-1-carboxylate. 4-((2-(aminomethyl)-4-iodophenoxy)methyl)piperidine-1-carboxylate and related derivatives have wide applications in medicinal chemistry and organic synthesis.

Synthesis Reference(s)

The Journal of Organic Chemistry, 70, p. 8590, 2005 DOI: 10.1021/jo051191x

Synthesis

(1)Synthesis of 5-iodo-2-hydroxybenzaldehyde oxime

Add 30g 5-iodo-2-hydroxybenzaldehyde to 270ml ethanol, dropwise add 17g hydroxylamine hydrochloride, room temperature stirring overnight, cooling, add water and ethyl acetate, extraction and partitioning, collection of the organic phase, drying, concentration, 23g 5-iodo-2-hydroxybenzaldehyde oxime was obtained.

(2) Synthesis of 2-hydroxy-5-iodobenzonitrile

Add 23g 5-iodo-2-hydroxybenzaldehyde oxime to 190ml acetic anhydride, heat and reflux stirring for 2 hours, concentrate, pour the residue into ice water, add ethyl acetate to extract the liquid, collect the organic phase, dry, concentrate, and get 16g 2-hydroxy-5-iodobenzonitrile separated by column.

2-HYDROXY-5-IODO-BENZONITRILE(685103-95-1)Related Product Information

• 2-hydroxy-5-iodonicotinic acid
• 5-Chloro-2-hydroxypyrazine
• 5-FLUORO-2-HYDROXY-3-NITROPYRIDINE
• Ethyl 2-hydroxy-5-nitronicotinate
• 5-bromo-6-hydroxypyridine-3-carbonitrile
• 2-(4-BROMOPHENYL)PROPAN-2-OL
• 5-AMINOMETHYL-1H-PYRIDIN-2-ONE
• 2-HYDROXY-3-PHENYLPYRIDINE
• 5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE
• 5-BROMO-3-CHLORO-2-HYDROXYPYRIDINE
• 3-BroMo-6-chloropyridin-2-ol
• 2-HYDROXY-5-METHYLPYRAZINE
• 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE
• 6-CHLORO-1,3-DIHYDRO-2H-IMIDAZO[4,5-B]PYRIDIN-2-ONE
• 3-Cyano-2-hydroxy-5-iodopyridine
• 2-HYDROXY-5-IODO-BENZONITRILE
• 5-iodo-2-methoxybenzonitrile
• AKOS B029124