4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide
4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide Basic information
- Product Name:
- 4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide
- Synonyms:
-
- [2H5]-Amisulpride
- Amisulpride Impurity 27
- Amisulpride Hydrochloride D5Q: What is Amisulpride Hydrochloride D5 Q: What is the CAS Number of Amisulpride Hydrochloride D5 Q: What is the storage condition of Amisulpride Hydrochloride D5 Q: What are the applications of Amisulpride Hydrochloride D5
- 4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide
- Guaiacol Impurity 28
- 4-amino-5-(ethanesulfonyl)-N-({1-[(1,1,2,2,2-2H?)ethyl]pyrrolidin-2-yl}methyl)-2-methoxybenzamide
- CAS:
- 1216626-17-3
- MF:
- C17H22D5N3O4S
- MW:
- 374.50978889
- Mol File:
- 1216626-17-3.mol
4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Chloroform: slightly soluble,Methanol: slightly soluble
- form
- A solid
- color
- White to off-white
- Stability:
- Hygroscopic
4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide Usage And Synthesis
Description
Amisulpride-d5 is intended for use as an internal standard for the quantification of amisulpride by GC- or LC-MS. Amisulpride is a dopamine D2 and D3 receptor antagonist (Kis = 3 and 3.5 nM, respectively). It is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT2B, 5-HT7, and 5-HT7A (Kis = 13, 11.5, and 135.5 nM, respectively). It is selective for these receptors over a panel of 39 additional receptors, ion channels, and transporters (Kis = >1,000 nM for all). Amisulpride increases 7-OH-DPAT-induced decreases in dopamine and acetylcholine release in electrically stimulated rat striatal slices (EC50s = 2.2 and 1.2 nM, respectively). It increases the levels of dopamine and the dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in rat striatum and nucleus accumbens when administered intraperitoneally at a dose of 10 mg/kg. Amisulpride decreases immobility time in the forced swim test in rats, as well as reduces stress-induced decreases in sucrose consumption in a rat model of depression induced by chronic mild stress.
Uses
Labelled Amisulpride (A633250). Amisulpride is a neuroleptic agent, an analogue of Sulpiride (S689145). Amisulpride is used as an antipsychotic. Amisulpride is a dopamine receptor antagonist.
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4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide(1216626-17-3)Related Product Information
- 4-AMino-N-[(1-ethyl-2-pyrrolidinyl)Methyl]-5-(ethylsulfonyl)- 2-MethoxybenzaMide N-Oxide
- 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-iodo-2-methoxybenzamide
- N-Des[(1-ethyl-2-pyrrolidinyl)Methyl]-N-(1-ethyl-3-piperidinyl) AMisulpride
- 2-(Aminomethyl)-1-ethylpyrrolidine
- Amisulpride
- [[p-(2-methoxyethyl)phenoxy]methyl]oxirane
- 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid
- Amisulpride EP Impurity H
- AMisulpride IMpurity D
- DesMethyl AMisulpride