BETA-AMANITIN
BETA-AMANITIN Basic information
- Product Name:
- BETA-AMANITIN
- Synonyms:
-
- BETA-AMANITIN
- ,12,17,18,19,20,21,22,23,23a-octadecahydro-29-sec-butyl-2,14-dihydroxy-21-(2,3
- 1-l-asparticacid-alpha-amaniti
- 8,20,23,24,27,30,33-octaoxo--dihydroxy-1-methylpropyl)-11-oxide
- beta-amatoxin
- B-amanitin from amanita phalloides
- alpha-Amanitin, 1-l-aspartic acid-
- beta-Amanitine
- CAS:
- 21150-22-1
- MF:
- C39H53N9O15S
- MW:
- 919.95
- EINECS:
- 244-244-8
- Product Categories:
-
- Cell Signaling and Neuroscience
- DNA-RNA Transcription RegulatorsCell Signaling and Neuroscience
- Gene Regulation and Expression
- Mushroom
- Toxins and Venoms
- Mol File:
- 21150-22-1.mol
BETA-AMANITIN Chemical Properties
- Melting point:
- 300°
- Boiling point:
- 1599.6±65.0 °C(Predicted)
- Density
- 1.1725 (rough estimate)
- refractive index
- 1.7400 (estimate)
- storage temp.
- −20°C
- solubility
- Water: 1 mg/ml
- pka
- 4.02±0.10(Predicted)
- form
- White to off-white powder.
- color
- White to off-white
Safety Information
- Hazard Codes
- T+
- Risk Statements
- 26/27/28
- Safety Statements
- 7-28-36/37/39-45
- RIDADR
- UN 3462 6.1/PG 1
- WGK Germany
- 3
- RTECS
- NJ8324000
- HazardClass
- 6.1(a)
- PackingGroup
- I
- HS Code
- 2934999090
- Toxicity
- LD50 i.p. in albino mice: 0.4 mg/kg (Wieland, Wieland)
MSDS
- Language:English Provider:SigmaAldrich
BETA-AMANITIN Usage And Synthesis
Acute toxicity
peritoneal-mouse LD50: 0.4 mg/kg; unnamed-mouse LD50: 0.4 mg/kg
Mechanism of action
β-Amanitin is a cyclic peptide found in several species of the Amanita genus, as well as other poisonous fungi. It inhibits RNA polymerase II and III but not RNA polymerase I or bacterial RNA polymerase, thus preventing mammalian protein synthesis. The biological activity of this toxin is similar to that of α-amanitin but differs structurally by the presence of a carboxyl group, which is useful for coupling reactions.
Uses
β-Amanitin from Amanita phalloides has been used:
- as a calibration standard for the quantification of β-Amanitin using liquid chromatography-high resolution-mass spectrometry/mass spectrometry (LC-HR-MS/MS) method.
- to determine its concentration in urine samples by capillary zone electrophoresis (CZE).
- in the analysis of β-amanitin in toxic mushrooms by liquid chromatography coupled to time-of-flight mass spectrometry.
Uses
As a tool in molecular biology.
General Description
β-Amanitin belongs to the family of amatoxins. Amanitins are made of bicyclic octapeptides. β-Amanitin is composed of a carboxyl group and is acidic in nature.
Biochem/physiol Actions
Toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but not RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis.
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