ALPHA-AMANITIN
ALPHA-AMANITIN Basic information
- Product Name:
- ALPHA-AMANITIN
- Synonyms:
-
- Aids004473
- Aids-004473
- AMANITIN, a-(RG)
- AMANITIN, a-(RG)(CALL)
- cyclo[L-Asparaginyl-4-hydroxy-L-proly-(R-4,5-dihydroxy-L-isoleucyl-6-hydroxy-2-mercapto-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl]cyclic(4-8)-sulfide(R)-S-oxide
- alpha-AMantine, froM AManita Phalloides
- Α-AMANITIN
- AMANITIN, A-
- CAS:
- 23109-05-9
- MF:
- C39H54N10O14S
- MW:
- 918.98
- EINECS:
- 245-432-2
- Product Categories:
-
- Alkaloids
- DNA-RNA Transcription RegulatorsCell Signaling and Neuroscience
- Gene Regulation and Expression
- Cell Signaling and Neuroscience
- Mushroom
- Toxins and Venoms
- Enzyme Inhibitors
- Enzyme Inhibitors by Type
- Other
- Miscellaneous Enzyme
- inhibitor
- Mol File:
- 23109-05-9.mol
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ALPHA-AMANITIN Chemical Properties
- Melting point:
- 254-255 °C(lit.)
- alpha
- D20 +191°
- Boiling point:
- 1622.2±65.0 °C(Predicted)
- Density
- 1.1626 (rough estimate)
- refractive index
- 1.7400 (estimate)
- storage temp.
- −20°C
- solubility
- H2O: 1.0 mg/mL
- form
- powder
- pka
- 9.63±0.70(Predicted)
- color
- white to light yellow
- optical activity
- +19120 (H2O)
- Water Solubility
- Soluble to 5 mM in ethanol and to 5 mM in water
- Merck
- 13,370
- BRN
- 1071138
- InChIKey
- CIORWBWIBBPXCG-PWKRRBCNNA-N
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Safety Information
- Hazard Codes
- T+
- Risk Statements
- 26/27/28-33-26/28
- Safety Statements
- 36/37/39-45-36/37-28
- RIDADR
- UN 3462 6.1/PG 2
- WGK Germany
- 3
- RTECS
- BD6195000
- F
- 8-10-18-21
- HazardClass
- 6.1(a)
- PackingGroup
- I
- HS Code
- 2934999090
- Hazardous Substances Data
- 23109-05-9(Hazardous Substances Data)
- Toxicity
- LD50 i.p. in albino mice: 0.1 mg/kg (Wieland, Wieland)
MSDS
- Language:English Provider:SigmaAldrich
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ALPHA-AMANITIN Usage And Synthesis
Uses
α-Amanitin has been used:
- for inducing transcriptional arrest in NT2 cells prior to immunofluorescence assay
- to induce nephrotoxicity in mice renal tissues
- to induce and analyse genotoxicity in mice bone marrow cells by cell viability assay, comet assay and chromosomal aberration assay
Biological Activity
α-amanitin, the most deleterious toxin of a. phalloides to humans, inhibits rna polymerase ii (rnapii), causing hepatic and renal failure.
Biochem/physiol Actions
The major toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but does not inhibit RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis.
storage
Store at -20°C
ALPHA-AMANITINSupplier
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