Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Natural Products >  Alkaloids >  ALPHA-AMANITIN

ALPHA-AMANITIN

Basic information Safety Supplier Related

ALPHA-AMANITIN Basic information

Product Name:
ALPHA-AMANITIN
Synonyms:
  • Aids004473
  • Aids-004473
  • AMANITIN, a-(RG)
  • AMANITIN, a-(RG)(CALL)
  • cyclo[L-Asparaginyl-4-hydroxy-L-proly-(R-4,5-dihydroxy-L-isoleucyl-6-hydroxy-2-mercapto-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl]cyclic(4-8)-sulfide(R)-S-oxide
  • alpha-AMantine, froM AManita Phalloides
  • Α-AMANITIN
  • AMANITIN, A-
CAS:
23109-05-9
MF:
C39H54N10O14S
MW:
918.98
EINECS:
245-432-2
Product Categories:
  • Alkaloids
  • DNA-RNA Transcription RegulatorsCell Signaling and Neuroscience
  • Gene Regulation and Expression
  • Cell Signaling and Neuroscience
  • Mushroom
  • Toxins and Venoms
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Type
  • Other
  • Miscellaneous Enzyme
  • inhibitor
Mol File:
23109-05-9.mol
More
Less

ALPHA-AMANITIN Chemical Properties

Melting point:
254-255 °C(lit.)
alpha 
D20 +191°
Boiling point:
1622.2±65.0 °C(Predicted)
Density 
1.1626 (rough estimate)
refractive index 
1.7400 (estimate)
storage temp. 
−20°C
solubility 
H2O: 1.0 mg/mL
form 
powder
pka
9.63±0.70(Predicted)
color 
white to light yellow
Water Solubility 
Soluble to 5 mM in ethanol and to 5 mM in water
Merck 
13,370
BRN 
1071138
More
Less

Safety Information

Hazard Codes 
T+
Risk Statements 
26/27/28-33-26/28
Safety Statements 
36/37/39-45-36/37-28
RIDADR 
UN 3462 6.1/PG 2
WGK Germany 
3
RTECS 
BD6195000
8-10-18-21
HazardClass 
6.1(a)
PackingGroup 
I
HS Code 
2934999090
Hazardous Substances Data
23109-05-9(Hazardous Substances Data)
Toxicity
LD50 i.p. in albino mice: 0.1 mg/kg (Wieland, Wieland)

MSDS

More
Less

ALPHA-AMANITIN Usage And Synthesis

Uses

α-Amanitin has been used:

  • for inducing transcriptional arrest in NT2 cells prior to immunofluorescence assay
  • to induce nephrotoxicity in mice renal tissues
  • to induce and analyse genotoxicity in mice bone marrow cells by cell viability assay, comet assay and chromosomal aberration assay

Biological Activity

α-amanitin, the most deleterious toxin of a. phalloides to humans, inhibits rna polymerase ii (rnapii), causing hepatic and renal failure.

Biochem/physiol Actions

The major toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but does not inhibit RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis.

storage

Store at -20°C

ALPHA-AMANITINSupplier

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Email
waley188@sohu.com
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611