Basic information Safety Supplier Related

4-HYDROPEROXY CYCLOPHOSPHAMIDE

Basic information Safety Supplier Related

4-HYDROPEROXY CYCLOPHOSPHAMIDE Basic information

Product Name:
4-HYDROPEROXY CYCLOPHOSPHAMIDE
Synonyms:
  • 4-HYDROPEROXY CYCLOPHOSPHAMIDE
  • ,2-oxide
  • 2-(bis(2-chloroethyl)amino)-4-hydroperoxytetrahydro-2h-1,3,2-oxazaphosphorin
  • 2-oxazophosphorine,2-(bis(2-chloroethyl)amino)-4-hydroperoxytetrahydro-2h-3
  • 4-hydroperoxyphosphamide
  • 4-oohcyclophosphamide
  • perfosfaMide, 4-hydroperoxycyclophosphaMide
  • 4-peroxy-cpa
CAS:
39800-16-3
MF:
C7H15Cl2N2O4P
MW:
293.08
Product Categories:
  • Various Metabolites and Impurities
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Phosphorylating and Phosphitylating Agents
Mol File:
39800-16-3.mol
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4-HYDROPEROXY CYCLOPHOSPHAMIDE Chemical Properties

Melting point:
100-103°C
Boiling point:
419.9±55.0 °C(Predicted)
Density 
1.46±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -86°C Freezer, Under Inert Atmosphere
solubility 
Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly), DCM
form 
Solid
pka
11.06±0.20(Predicted)
color 
White to Pale Yellow
Stability:
Hygroscopic, Temperature Sensitive
InChI
InChI=1S/C7H16Cl2N2O4P/c8-2-4-11(5-3-9)16(13)10-7(15-12)1-6-14-16/h7,10,12,16H,1-6H2/q-1/p-1
InChIKey
ZZENMHFAKYKQCX-UHFFFAOYSA-M
SMILES
[O-]OC1CCOP(N(CCCl)CCCl)([O-])N1
CAS DataBase Reference
39800-16-3
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4-HYDROPEROXY CYCLOPHOSPHAMIDE Usage And Synthesis

Chemical Properties

White Solid

Uses

A metabolite of Cyclophosphamide. Antineoplastic; bone marrow purging agent.

Definition

ChEBI: The active metabolite of the nitrogen mustard cyclophosphamide with potent antineoplastic and immunosuppressive properties.

Biological Activity

Active metabolite of the nitrogen mustard cyclophosphamide.
4-Hydroperoxycyclophosphamide is the active metabolite of the nitrogen mustard cyclophosphamide. 4-Hydroperoxycyclophosphamide exhibits potent antineoplastic and immunosuppressive activities.

in vivo

4-Hydroperoxy cyclophosphamide (200 mg/kg intraperitoneally injected) kills Caspase-independent T cells and B cells in mice[1].

Animal Model:BALB/c mice[1]
Dosage:200 mg/kg
Administration:i.p.
Result:Exhibited a marked depletion of immature double-positive CD4 t CD8 t thymocytes and mature single-positive CD4+ and CD8+ T cells.

4-HYDROPEROXY CYCLOPHOSPHAMIDESupplier

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4-HYDROPEROXY CYCLOPHOSPHAMIDE(39800-16-3)Related Product Information