GIGAVLKVLTTGLPALISWIKRKRQ-OH
GIGAVLKVLTTGLPALISWIKRKRQ-OH Basic information
- Product Name:
- GIGAVLKVLTTGLPALISWIKRKRQ-OH
- Synonyms:
-
- MELITTIN
- MELITTIN (FREE ACID)
- GIGAVLKVLTTGLPALISWIKRKRQ-OH
- GLY-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-THR-THR-GLY-LEU-PRO-ALA-LEU-ILE-SER-TRP-ILE-LYS-ARG-LYS-ARG-GLN-GLN: GIGAVLKVLTTGLPALISWIKRKRQQ
- Melittin trifluoroacetate
- CAS:
- 123168-46-7
- MF:
- C131H228N38O32
- MW:
- 2847.45
- Mol File:
- Mol File
GIGAVLKVLTTGLPALISWIKRKRQ-OH Usage And Synthesis
Uses
Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways[1][2].
in vivo
Melittin (intraperitoneal inoculation) increases 13,14-dihydro-15-keto-PGE2 levels in peripheral blood of mice[1].
References
[1] Hassid A, Levine L. Stimulation of phospholipase activity and prostaglandin biosynthesis by melittin in cell culture and in vivo. Res Commun Chem Pathol Pharmacol. 1977. PMID:928951
[2] Memariani H, Memariani M. Anti-fungal properties and mechanisms of melittin. Appl Microbiol Biotechnol. 2020 Aug;104(15):6513-6526. DOI:10.1007/s00253-020-10701-0
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