CODEINE PHOSPHATE
CODEINE PHOSPHATE Basic information
- Product Name:
- CODEINE PHOSPHATE
- Synonyms:
-
- CODEINE PHOSPHATE
- CODEINE PHOSPHATE HEMIHYDRATE
- CODEINIUM PHOSPHATE HEMIHYDRATE
- METHYLMORPHINE PHOSPHATE HEMIHYDRATE
- N-METHYLNORCODEINE HEMIHYDRATE
- MORPHINE-3-METHYL ETHER HEMIHYDRATE
- Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5.alpha.,6.alpha.)-, phosphate (salt), hydrate (2:2:1)
- CODEINEPHOSPHATE,USP
- CAS:
- 41444-62-6
- MF:
- C18H24NO7P
- MW:
- 397.36
- EINECS:
- 639-473-9
- Product Categories:
-
- API
- Mol File:
- 41444-62-6.mol
CODEINE PHOSPHATE Chemical Properties
- solubility
- Freely soluble in water, slightly soluble or very slightly soluble in ethanol (96 per cent).
- form
- A crystalline solid
- BCS Class
- 3
- CAS DataBase Reference
- 41444-62-6
CODEINE PHOSPHATE Usage And Synthesis
Chemical Properties
White or almost white, crystalline powder or small, colourless crystals.
Originator
Actacode Linctus,Sigma
Uses
Antitussive; analgesic (narcotic).
brand name
Ambenyl Cough Syrup (Parke-Davis); Colrex Compound (Solvay Pharmaceuticals).
Therapeutic Function
Narcotic analgesic, Antitussive
Clinical Use
Codeine is used extensively to treat moderate to mild pain. Codeine is a weak μ agonist, but approximately 10% of an oral dose (30–60 mg) is metabolized to morphine, which contributes significantly to its analgesic effect. The plasma half-life of codeine after oral dose is 3.5 hours. The dose of codeine needed to produce analgesia after parenteral dose causes releases of histamine sufficient to produce hypotension, pruritus, and other allergic responses. Thus, administration of codeine by parenteral route is not recommended.
Veterinary Drugs and Treatments
In small animal medicine, codeine is used principally as an oral analgesic when salicylates are not effective and parenteral opiates are not warranted. It may also be useful as an antitussive or an antidiarrheal.
Drug interactions
Potentially hazardous interactions with other drugs
Antibacterials: metabolism increased by rifampicin.
Antidepressants: possible CNS excitation or
depression with MAOIs - avoid concomitant use,
and for 2 weeks after stopping MAOI; possible
CNS excitation or depression with moclobemide;
increased sedative effects with tricyclics.
Antihistamines: increased sedative effects with
sedating antihistamines.
Antipsychotics: enhanced hypotensive and sedative
effects.
Dopaminergics: avoid with selegiline.
Nalmefene: avoid concomitant use.
Sodium oxybate: enhanced effect of sodium oxybate
- avoid.
Metabolism
Codeine is metabolised by O- and N-demethylation in
the liver to morphine, norcodeine, and other metabolites
including normorphine and hydrocodone. Metabolism to
morphine is mediated by the cytochrome P450 isoenzyme
CYP2D6, which shows genetic polymorphism.
Codeine and its metabolites are excreted almost entirely
by the kidney, mainly as conjugates with glucuronic acid.
CODEINE PHOSPHATE(41444-62-6)Related Product Information
- NOSCAPINE HYDROCHLORIDE
- S-Carboxymethyl-L-cysteine
- CODEINE
- CODEINE PHOSPHATE
- PHOLCODINE IMP. B (PHARMEUROPA) AS PHOSPHATE HEMIHYDRATE: CODEINE PHOSPHATE HEMIHYDRATE[CONTROLLED SUBSTANCE]
- CODEINE PHOSPHATE, DIHYDRATE)
- Codeine phosphate (6CI, 7CI),Codeine phosphate (1:1)
- HYDROCODONE HYDROGEN TARTRATE 2.5-HYDRATEIMP. C (EP) AS PHOSPHATE HEMIHYDRATE:CODEINE PHOSPHATE HEMIHYDRATE[CONTROLLED SUBSTANCE]
- CODEINE PHOSPHATE, SEQUIHYDRATE)
- ETHYLMORPHINE HYDROCHLORIDE IMP. C (EP) AS PHOSPHATE HEMIHYDRATE: CODEINE PHOSPHATE HEMIHYDRATE [CONTROLLED SUBSTANCE]
- CODEINE PHOSPHATE HEMIHYDRATE [CONTROLLED SUBSTANCE]
- MORPHINE HYDROCHLORIDE IMP. A (EP) AS PHOSPHATE HEMIHYDRATE: CODEINE PHOSPHATE HEMIHYDRATE[CONTROLLED SUBSTANCE]
- MORPHINE SULPHATE IMP. A (EP) AS PHOSPHATE HEMIHYDRATE: CODEINE PHOSPHATE HEMIHYDRATE[CONTROLLED SUBSTANCE]
- acecobarb
- migraleve
- 6-O-METHYLCODEINE PHOSPHATE
- Codeine phosphate sesquihydrate