QX-314 Chemical Properties

Melting point:

220 - 222°C

storage temp. 

Desiccate at RT

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

lyophilized solid

color 

White to Off-White

Water Solubility 

water: 3mg/mL

Specific Activity

40-60 Ci/mmol

Solvent

Ethanol:water (1:1)

Concentration

1 mCi/ml

Major Application

forensics and toxicology
pharmaceutical (small molecule)
veterinary

InChI

1S/C16H26N2O.BrH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H

InChIKey

DLHMKHREUTXMCH-UHFFFAOYSA-N

SMILES

[Br-].CC[N+](CC)(CC)CC(=O)Nc1c(C)cccc1C

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:SigmaAldrich

QX-314 Usage And Synthesis

Uses

Blocker of voltage-activated sodium channels

Uses

QX-314 bromide is a derivative of Lidocaine. It is a local anesthetic.

Biological Activity

Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na + channels. Intracellular QX 314 bromide also inhibits calcium currents in hippocampal CA1 pyramidal neurons.

QX-314(21306-56-9)Related Product Information

• Tetracaine hydrochloride
• Aconitine
• VERATRIDINE
• TETRODOTOXIN
• L-KAWAIN
• BATRACHOTOXIN
• PD 85639
• QX 314 CHLORIDE
• Lidocaine
• QX-314
• MONOETHYLGLYCINEXYLIDIDE
• 2-AMINO-N-(2,6-DIMETHYLPHENYL)ACETAMIDE
• LIDOCAINE, N-ETHYL BROMIDE QUATERNARY SALT, [N-ETHYL-1-3H]
• QX-314Cl- Salt, Voltage-Gated Na+ Channel Blocker of VGSC of excitable cells, 0.29885kD
• QX314 Chloride Salt (2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride)
• N,N-Diethyl-N-(2-oxo-2-((2,4,6-trimethylphenyl)amino)ethyl)-2-propen-1 -aminium bromide
• QX314 Bromide (N-(2,6-Dimethylphenylcarbamoylmethyl) triethylammonium bromide)
• QX-314Br- Salt, Voltage-Gated Na+ Channel Blocker of VGSC of excitable cells, 0.3433kD