NOD1 ANTIBODY Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

Nod1/CARD4 is a cytosolic protein structually related to Apaf-1 and plant drug-resistance proteins that has been implicated in apoptosis and inflammatory responses to certain pathogenic bacteria. It contains an amino-terminal caspase recruitment domain that is linked to a central nucleotide-binding domain and is followed by carboxy-terminal leucine-rich repeats. Like Apaf-1, Nod1 induces apoptosis by a CARD/NBD-dependent activation of caspase-9. The primary function of Nod1 is thought to be as a sensor for certain pathogenic microbes and triggering inflammatory responses including the activation of NF-κB and JNK pathways. The LRR of Nod1 appears to be involved in recognition of microbial components and the CARD domain induces NF-κB activation in cooperation with the CARD containing kinase, RICK/RIP2/CARDIAK. Mutations in Nod1 have been linked increased susceptibility to asthma and inflammatory bowel disease.

References

[1] Inohara, N. et al. (1999) J. Biol. Chem. 274, 14560-14567.
[2] Inohara, N. and Nuñez, G. (2003) Nat. Rev. Immunol. 3, 371-382.
[3] Fritz, J.H. et al. (2006) Nat .Immunol. 7, 1250-1257.
[4] Girardin, S.E. et al. (2001) EMBO Rep. 2, 736-742.
[5] Inohara, N. et al. (2001) J. Biol. Chem. 276, 2551-2554.
[6] Inohara, N. et al. (2000) J. Biol. Chem. 275, 27823-27831.
[7] Hysi, P. et al. (2005) Hum. Mol. Genet. 14, 935-941.
[8] McGovern, D.P. et al. (2005) Hum. Mol. Genet. 14, 1245-1250.

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