5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9α)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl ester Chemical Properties

Boiling point:

519.6±40.0 °C(Predicted)

Density 

1.14±0.1 g/cm3(Predicted)

storage temp. 

Storage temp. -20°C

pka

12.05±0.46(Predicted)

form 

Liquid (Density: 1.14±0.1 g/cm3)

color 

Colorless to light yellow

5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9α)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl ester Usage And Synthesis

Uses

BCN- exo- PEG3- NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. BCN- exo- PEG3- NH2 is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Biological Activity

BCN-?exo-?PEG3-?NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC 50

PEGs

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9α)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl ester(1841134-72-2)Related Product Information

• BCN-OH
• endo-BCN-PEG4-acid
• -
• exo BCN-O-PNB
• endo BCN-O-PNB
• endo-BCN-PEG4-NHS ester
• (1R,8S,9r)-bicyclo[6.1.0]nonan-9-ylmethanol