5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9β)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl ester Chemical Properties

Boiling point:

519.6±40.0 °C(Predicted)

Density 

1.14±0.1 g/cm3(Predicted)

storage temp. 

-20°C, sealed storage, away from moisture and light

form 

Oil

pka

12.05±0.46(Predicted)

color 

Light yellow to yellow

5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9β)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl ester Usage And Synthesis

Description

endo-BCN-PEG3-amine is a click chemistry linker containing a BCN and an amine group. The BCN group can react with azide-tagged biomolecules under mile condition. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

Uses

endo-BCN-PEG3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. endo-BCN-PEG3-NH2 is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9β)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl ester(1883512-27-3)Related Product Information

• BCN-OH
• endo-BCN-PEG4-acid
• exo BCN-O-PNB
• endo BCN-O-PNB
• endo-BCN-PEG4-NHS ester
• -
• (1R,8S,9r)-bicyclo[6.1.0]nonan-9-ylmethanol