Basic information Safety Supplier Related

12(S)-HETE

Basic information Safety Supplier Related

12(S)-HETE Basic information

Product Name:
12(S)-HETE
Synonyms:
  • 12(S)-HYDROXY-(5Z,8Z,10E,14Z)-EICOSATETRAENOIC ACID
  • 12(S)-HETE
  • 12(S)-HYDROXYEICOSA-5Z,8Z,10E,14Z-TETRAENOIC ACID
  • 12(S)-HETE Lipid Maps MS Standard
  • [S-(E,Z,Z,Z)]-12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
  • 12-L-Hydroxy-5,8,10,14-eicosatetraenoic Acid
  • 12(S)-HETE MaxSpecStandard
  • (12S,5Z,8Z,10E,14Z)-12-Hydroxyeicosatetraenoic acid
CAS:
54397-83-0
MF:
C20H32O3
MW:
320.47
EINECS:
200-578-6
Product Categories:
  • Aliphatics
  • Fatty Acid Derivatives & Lipids
  • Glycerols
  • Metabolites & Impurities
Mol File:
54397-83-0.mol
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12(S)-HETE Chemical Properties

Boiling point:
487.7±45.0 °C(Predicted)
Density 
0.984±0.06 g/cm3(Predicted)
Flash point:
14 °C
storage temp. 
-20°C
solubility 
0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml
form 
Liquid.
pka
4.75±0.10(Predicted)
color 
Colorless to light yellow
BRN 
2656104
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Safety Information

Hazard Codes 
F,Xi
Risk Statements 
11-36/37/38
Safety Statements 
7-16-26-36
RIDADR 
UN 1170 3/PG 2
WGK Germany 
1
8-10-23

MSDS

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12(S)-HETE Usage And Synthesis

Description

12(S)-HETE is the predominant lipoxygenase product of mammalian platelets. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 μM.

12(S)-HETE MaxSpec® standard is a quantitative grade standard of 12(S)-HETE that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 12(S)-HETE MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

Uses

A fatty acid metabolite of arachidonic acid (A765000). Potential biomarker for asthma monitoring and diagnosis. Stimulates protein kinase C-mediated release of cathepsin B from malignant cells. Used in the study of mechanisms controlling cell cycle arrest and induction of apoptosis in prostate cancer cells via 12-lipoxygenase inhibition..

Uses

12(S)-HETE is the predominant lipoxygenase product of mammalian platelets. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 μM.

Definition

ChEBI: A HETE having a (12S)-hydroxy group and (5Z)-, (8Z)-, (10E)- and (14Z)-double bonds.

Biochem/physiol Actions

12(S)-HETE is a bioactive lipid implicated in angiogenesis, growth, and metastasic action in tumor cell lines and in animal models. Arachidonate 12-lipoxygenase (12-LOX) converts arachidonic acid to 12(S)-(HETE). Alteration in 12-LOX expression or activity has been reported in various carcinomas including prostate carcinoma.

12(S)-HETESupplier

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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jkinfo@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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3bsc@sina.com
Chemsky (shanghai) International Co.,Ltd
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021-50135380
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shchemsky@sina.com
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
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meilunui@163.com
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Email
isunpharm@qq.com