12(S)-HPETE Chemical Properties

Boiling point:

518.0±50.0 °C(Predicted)

Density 

1.013±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml

form 

Liquid.

pka

4.75±0.10(Predicted)

12(S)-HPETE Usage And Synthesis

Description

12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the synthesis of 5(S)-HETE, leukotriene B₄ (LTB₄), and 5(S),12(S)-DiHETE. Rat lung metabolizes 12(S)-HpETE to 8,11,12- and 10,11,12-trihydroxyeicostrienoic acids. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and inhibits Ca²⁺/calmodulin-dependent protein kinase II from rat brain cortex.

Uses

12(S)-HPETE is a fatty acid and an activator of human blood leukocyte 5-LO.

Definition

ChEBI: 12(S)-HPETE is the (S)-enantiomer of 12-HPETE. It has a role as a mouse metabolite. It is functionally related to an icosa-5,8,10,14-tetraenoic acid. It is a conjugate acid of a 12(S)-HPETE(1-). It is an enantiomer of a 12(R)-HPETE.

12(S)-HPETE(71774-10-2)Related Product Information

• 12(S)-HPETE LIPID MAPS
• 12(S)-HPETE [1-14C]
• 12(R)-HPETE
• (+/-)12-HPETE
• 12(S)-HPETE
• (+/-)12-HETE
• 12(S)-HETE
• 1,5-HEPTADIEN-4-OL
• 1.3.7-OCTATRIENE