2-Bromo-5-chlorobenzaldehyde Chemical Properties

Melting point:

66 °C

Boiling point:

258 °C

Density 

1.698

Flash point:

110 °C

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

Crystalline

color 

Pale yellow

InChI

InChI=1S/C7H4BrClO/c8-7-2-1-6(9)3-5(7)4-10/h1-4H

InChIKey

IIISHLMCTDMUHH-UHFFFAOYSA-N

SMILES

C(=O)C1=CC(Cl)=CC=C1Br

CAS DataBase Reference

174265-12-4

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

22

Safety Statements 

24/25

RIDADR 

UN1993

HS Code 

29130000

2-Bromo-5-chlorobenzaldehyde Usage And Synthesis

Uses

2-Bromo-5-chlorobenzaldehyde is an important class of pharmaceutical intermediates which can be used in the synthesis of a variety of drugs. 2-Bromo-5-chlorobenzaldehyde can be used in the preparation of the compound 3-chloro-14-cyclohexyl-6-[2-(dimethylamino)ethyl]-7-oxo-5,6,7,8-tetrahydroindolo[2,1-a][2,5]benzo[di-acridine]-11-carboxylic acid, which can be used in the treatment or prevention of viral infections.

Synthesis

Step 2: Synthesis of 2-bromo-5-chlorobenzaldehyde; Preparation was carried out with reference to the literature method (J. Am. Chem. Soc. 2002, 124(7), 1354): a mixture of activated powdered 4A molecular sieves (800 mg/mmol of substrate), N-methylmorpholine-N-oxide (2 eq.) and 2-bromomethyl-5-chlorobenzaldehyde (1 eq.) was stirred for 2 hours at 0°C in a N -methylpyrrolidone (0.16 M) were stirred for 2 hours. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and the filtrate was subsequently concentrated under vacuum to afford the target product 2-bromo-5-chlorobenzaldehyde in 92% yield.

References

[1] Patent: WO2006/46030, 2006, A2. Location in patent: Page/Page column 28
[2] Journal of the American Chemical Society, 2002, vol. 124, # 7, p. 1354 - 1363

2-Bromo-5-chlorobenzaldehyde(174265-12-4)Related Product Information

• 1,2,4-Trichlorobenzene
• 1,2,3-Trichlorobenzene
• Chlorphenamine maleate
• 4-Chlorobenzaldehyde
• 2-Chlorobenzaldehyde
• Difluorochloromethane
• Bromine
• Pigment Green 36
• 2-BROMO-3-CHLORO-6-AMINO BENZOIC ACID
• 2-Bromo-5-chlorobenzoic acid
• METHYL 2-BROMO-5-CHLOROBENZOATE
• 4-BROMO-2-CHLOROBENZALDEHYDE,2-Chloro-4-bromobenzaldehyde
• 3-BROMO-4-CHLOROBENZALDEHYDE
• 2-chloro-5-bromobenzaldehyde
• Ethyl 5-bromo2-chlorobenzaldehyde
• 5-BROMO-2-CHLOROBENZALDEHYDE
• CHEMBRDG-BB 6488232
• (2S)-2-(2-BROMO-3-CHLOROPHENYL)PYRROLIDINE